Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14)

Cat. No.: HY-P990199 Purity: 95.00%: Data Sheet
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Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) is an anti-mouse Ly6G/Ly6C IgG2b monoclonal antibody. Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) can deplete granulocytes and monocytes. Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) can be used for researches on infection conditions and cancer such as pancreatic cancer and Orientia tsutsugamushi infection.

For research use only. We do not sell to patients.

Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Purity & Documentation
References
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Description

Isotype

Rat IgG2b kappa

Recommend Isotype Controls

Rat IgG2b kappa, Isotype Control

Species Reactivity

Mouse

In Vivo

Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) (100 μg, i.p., twice a week, until the end of the experiment) significantly delays tumor growth combined with T cell-engaging bispecific antibodies (T-BsAbs) in BALB/c mice bearing SW1990 tumors^[1].
Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) (250 μg, i.p., on day -1, 0, 1 and 2) does not significantly alter the skin and bacterial load in female C57BL/6 mice infected with Orientia tsutsugamushi^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	2-3×10⁶ SW1990 cells injected BALB/c mice (6-10 weeks)^[1]
Dosage:	100 μg, combined with T-BsAb (2 μg or 10 μg, i.v.)
Administration:	Intraperitoneal injection (i.p.), twice a week, until the end of the experiment
Result:	Improved survival rate and promoted T cell infiltration into tumors. Improved the immunosuppressive state in the tumor microenvironment and enhanced the efficacy of T-BsAb. Reduced immunosuppressive myeloid cells in the tumor microenvironment.

Animal Model:	Orientia tsutsugamushi infected female C57BL/6 mice (8-10 weeks)^[2]
Dosage:	250 μg
Administration:	Intraperitoneal injection (i.p.), on day -1, 0, 1 and 2
Result:	Reduced the number of neutrophils. Did not significantly alter the skin. Did not alter draining lymph nodes (dLN) or bacterial load in the internal organs.

Application

in vivo neutrophil depletion; Immunohistochemistry (paraffin); Immunohistochemistry (frozen); Imm

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14)]

Formulation

Please refer to the lot-specific COA for specific buffer information.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

Select Batch:

Data Sheet (260 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Long AW, et al. Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma. J Hematol Oncol. 2024 Apr 23;17(1):20. [Content Brief]

[2]. Liang Y, et al. CCR7/dendritic cell axis mediates early bacterial dissemination in Orientia tsutsugamushi-infected mice. Front Immunol. 2022 Dec 22;13:1061031. [Content Brief]

Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14)OthersLy6G/Ly6CgranulocytesmonocytesPDACSW1990OtInhibitorinhibitorinhibit

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