Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14)
Based on 1 Customer Validation
Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) is an anti-mouse Ly6G/Ly6C IgG2b monoclonal antibody. Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) can deplete granulocytes and monocytes. Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) can be used for researches on infection conditions and cancer such as pancreatic cancer and Orientia tsutsugamushi infection.
For research use only. We do not sell to patients.
- Purity : 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Rat IgG2b kappa
Recommend Isotype Controls
Species Reactivity
Mouse
In Vivo
Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) (250 μg, i.p., on day -1, 0, 1 and 2) does not significantly alter the skin and bacterial load in female C57BL/6 mice infected with Orientia tsutsugamushi[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:2-3×106 SW1990 cells injected BALB/c mice (6-10 weeks)[1]
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Dosage:100 μg, combined with T-BsAb (2 μg or 10 μg, i.v.)
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Administration:Intraperitoneal injection (i.p.), twice a week, until the end of the experiment
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Result:Improved survival rate and promoted T cell infiltration into tumors.
Improved the immunosuppressive state in the tumor microenvironment and enhanced the efficacy of T-BsAb.
Reduced immunosuppressive myeloid cells in the tumor microenvironment.
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Animal Model:Orientia tsutsugamushi infected female C57BL/6 mice (8-10 weeks)[2]
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Dosage:250 μg
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Administration:Intraperitoneal injection (i.p.), on day -1, 0, 1 and 2
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Result:Reduced the number of neutrophils.
Did not significantly alter the skin.
Did not alter draining lymph nodes (dLN) or bacterial load in the internal organs.
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo neutrophil depletion; Immunohistochemistry (paraffin); Immunohistochemistry (frozen); Imm
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Long AW, et al. Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma. J Hematol Oncol. 2024 Apr 23;17(1):20. [Content Brief]
[2]. Liang Y, et al. CCR7/dendritic cell axis mediates early bacterial dissemination in Orientia tsutsugamushi-infected mice. Front Immunol. 2022 Dec 22;13:1061031. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) Related Classifications
HY-P990199 Related Classifications
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