GATAD2A Antibody (YA1966)

Cat. No.: HY-P82221: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

GATAD2A Antibody (YA1966) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GATAD2A.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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GATAD2A Antibody (YA1966) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

GATAD2A Antibody (YA1966) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GATAD2A.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 68 kDa;

Observed band size: 65,68 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

Q86YP4

Gene ID

54815 [NCBI]

Immunogen

A synthesized peptide derived from human p66 alpha aa175-236.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
FC FC: Flow Cytometry	1:50-1:100

Sensitivity	Endogenous	Purity	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179)

Subcellular Localization：Nucleus speckle; Nucleus; Chromosome

Expression：
Tissue_specificity:Ubiquitous, both in human tissues

Isoforms & Post-Translational Modification：Q86YP4 has 3 isomers: Q86YP4-1: 68063 Da (predicted); Q86YP4-2: 65225 Da (predicted); Q86YP4-3: 68134 Da (predicted).

Subunit：Homooligomer (PubMed:27732854). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:16428440, PubMed:27732854, PubMed:28977666, PubMed:33283408). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:16428440, PubMed:27732854, PubMed:28977666, PubMed:33283408). Component of the MeCP1 histone deacetylase complex (PubMed:21490301). Interacts with CDK2AP1 (PubMed:33283408). Interacts with CHD4 (PubMed:33283408). Interacts with ERCC6 (PubMed:26030138). Interacts with HDAC1 (PubMed:33283408). Interacts with HDAC2 (PubMed:33283408). Interacts with MBD2; this interaction is required for the enhancement of MBD2-mediated repression and for targeting to the chromatin (PubMed:12183469, PubMed:16415179, PubMed:21490301, PubMed:27732854, PubMed:33283408). Interacts with MBD3 (PubMed:12183469, PubMed:27732854). Interacts with MTA2 (PubMed:33283408). Interacts with ZMYND8 (PubMed:27732854, PubMed:35916866). Interacts with histone tails, including that of histones H2A, H2B, H3 and H4, the interaction is reduced by histone acetylation (PubMed:16415179)

Database

Entrez Gene: 54815 Human ; 234366 Mouse ;

SwissProt: Q86YP4 Human ; Q8CHY6 Mouse ;

OMIM: 614997 Human

Research Field

Synonyms

GATAD2A; Hp66alpha; P66 alpha; p66alpha

Documentation

Select Batch:

Data Sheet (234 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

GATAD2A Antibody (YA1966) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GATAD2A Antibody (YA1966)

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GATAD2A Antibody (YA1966) Related Classifications

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