GATAD2A - GATA zinc finger domain containing 2A Gene

Also Known as p66alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54815

About GATAD2A

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,385,843-19,508,932 (from NCBI)

This gene has 13 transcripts (splice variants), 282 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 18.1), spleen (RPKM 10.8) and 25 other tissues.

Summary

Enables protein-macromolecule adaptor activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]

GATAD2A Products (33)

mRNA Protein Name
NM_001300946.3 NP_001287875.1 transcriptional repressor p66-alpha isoform 1
NM_001359631.2 NP_001346560.1 transcriptional repressor p66-alpha isoform 3
NM_001384511.1 NP_001371440.1 transcriptional repressor p66-alpha isoform 1
NM_001384512.1 NP_001371441.1 transcriptional repressor p66-alpha isoform 1
NM_001384513.1 NP_001371442.1 transcriptional repressor p66-alpha isoform 1
NM_001384514.1 NP_001371443.1 transcriptional repressor p66-alpha isoform 1
NM_001384515.1 NP_001371444.1 transcriptional repressor p66-alpha isoform 1
NM_001384516.1 NP_001371445.1 transcriptional repressor p66-alpha isoform 1
NM_001384517.1 NP_001371446.1 transcriptional repressor p66-alpha isoform 1
NM_001384518.1 NP_001371447.1 transcriptional repressor p66-alpha isoform 1
NM_001384519.1 NP_001371448.1 transcriptional repressor p66-alpha isoform 1
NM_001384521.1 NP_001371450.1 transcriptional repressor p66-alpha isoform 1
NM_001384522.1 NP_001371451.1 transcriptional repressor p66-alpha isoform 1
NM_001384523.1 NP_001371452.1 transcriptional repressor p66-alpha isoform 1
NM_001384524.1 NP_001371453.1 transcriptional repressor p66-alpha isoform 1
NM_001384525.1 NP_001371454.1 transcriptional repressor p66-alpha isoform 1
NM_001384526.1 NP_001371455.1 transcriptional repressor p66-alpha isoform 1
NM_001384527.1 NP_001371456.1 transcriptional repressor p66-alpha isoform 1
NM_001384528.1 NP_001371457.1 transcriptional repressor p66-alpha isoform 1
NM_001384529.1 NP_001371458.1 transcriptional repressor p66-alpha isoform 2
NM_001384530.1 NP_001371459.1 transcriptional repressor p66-alpha isoform 2
NM_001384531.1 NP_001371460.1 transcriptional repressor p66-alpha isoform 2
NM_001384532.1 NP_001371461.1 transcriptional repressor p66-alpha isoform 2
NM_001384533.1 NP_001371462.1 transcriptional repressor p66-alpha isoform 2
NM_001384534.1 NP_001371463.1 transcriptional repressor p66-alpha isoform 3
NM_001384535.1 NP_001371464.1 transcriptional repressor p66-alpha isoform 3
NM_001384536.1 NP_001371465.1 transcriptional repressor p66-alpha isoform 3
NM_001384537.1 NP_001371466.1 transcriptional repressor p66-alpha isoform 4
NM_001384538.1 NP_001371467.1 transcriptional repressor p66-alpha isoform 5
NM_001384539.1 NP_001371468.1 transcriptional repressor p66-alpha isoform 6
NM_001384540.1 NP_001371469.1 transcriptional repressor p66-alpha isoform 7
NM_001384541.1 NP_001371470.1 transcriptional repressor p66-alpha isoform 7
NM_017660.5 NP_060130.3 transcriptional repressor p66-alpha isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12183469 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
12183469 GOA
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
9790534 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12183469 GOA
Cellular Component GO Annotation Evidence References Source
part of NuRD complex IDA
IDA: Inferred from direct assay
12183469 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12183469 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcriptional repressor p66-alpha

  • GATA zinc finger domain-containing protein 2A

GATAD2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GATAD2A Q86YP4 KRT32 Homo sapiens Q14532
Y2H Prey Pooling
32296183
Intra
GATAD2A Q86YP4 KRT32 Homo sapiens Q14532
Y2H Array
32296183
Intra
GATAD2A Q86YP4 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
GATAD2A Q86YP4 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
GATAD2A Q86YP4 MBD3L1 Homo sapiens Q8WWY6
Y2H Prey Pooling
32296183
Intra
GATAD2A Q86YP4 MBD3L1 Homo sapiens Q8WWY6
Validated Y2H
32296183
Intra
GATAD2A Q86YP4 MBD3L1 Homo sapiens Q8WWY6
Y2H Array
32296183
Intra
GATAD2A Q86YP4 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
GATAD2A Q86YP4 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
GATAD2A Q86YP4 MBD2 Homo sapiens Q9UBB5
Anti Tag CoIP
33961781
Intra
GATAD2A Q86YP4 MBD2 Homo sapiens Q9UBB5
Validated Y2H
32296183
Intra
GATAD2A Q86YP4 MBD2 Homo sapiens Q9UBB5
Lumier
32814053
Intra
GATAD2A Q86YP4 MBD2 Homo sapiens Q9UBB5
Y2H Array
32296183
Intra
GATAD2A Q86YP4 MBD2 Homo sapiens Q9UBB5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

GATAD2A Antibodies

Cat. No. Product Name Application Reactivity
HY-P82221 GATAD2A Antibody (YA1966) WB, IHC-P, ICC/IF, FC Human, Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10326 Z-ATAD-FMK Inhibitor / Unkown
HY-RS05296 GATAD2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GATAD2A RGD RGD:1310596
Felis catus GATAD2A VGNC VGNC:62477
Mus musculus GATAD2A MGD MGI:2384585
Bos taurus GATAD2A VGNC VGNC:29271
Canis familiaris GATAD2A VGNC VGNC:41126
Others GATAD2A NCBI