country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-163619

Copy Link Print Information

Anticancer agent 227

Anticancer agent 227 (compound YNU-1c) is a potent anticancer agent. Anticancer agent 227 shows antiproliferative activity. Anticancer agent 227 induces apoptosis and mitophagy.

For research use only. We do not sell to patients.

Formula: C₃₈H₂₇Cl₅N₂O₂PRh
Molecular Weight:854.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Anticancer agent 227 Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Hot Topics (2)
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Anticancer agent 227 (compound YNU-1c) is a potent anticancer agent. Anticancer agent 227 shows antiproliferative activity. Anticancer agent 227 induces apoptosis and mitophagy^[1].

In Vitro

Anticancer agent 227 (compound YNU-1c) (0-50 µM; 48 h) shows antiproliferative activity with IC₅₀s of 0.19, 0.13, >50 µM for HepG2, HCC1806, HL-7702 cells, respectively^[1].
Anticancer agent 227 (0.13 µM; 48 h) induces apoptosis by increasing the expression of cytochrome c and cleaved caspase-3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HepG2, HCC1806, HL-7702, SF1, SF2 cells
Concentration:

0-50 μM
Incubation Time:

48 h
Result:

Showed antiproliferative activity with IC₅₀s of 0.19, 0.13, >50, >384.6, >263.2 μM for HepG2, HCC1806, HL-7702, SF1, SF2 cells, respectively.

Western Blot Analysis^[1]

Cell Line:

HCC1806 cells
Concentration:

0.13 µM
Incubation Time:

48 h
Result:

Upregulated the expression of cytochrome c and cleaved caspase-3.

In Vivo

Anticancer agent 227 (5 mg/kg; i.p.; every 2 days for 21 days) shows antitumor activity in HCC1806 tumor-bearing nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Balb/c nude mice (HCC1806 cells)^[1]
Dosage:

5 mg/kg
Administration:

I.p.; every 2 days for 21 days
Result:

Effectively inhibited HCC1806 tumor growth, reduced tumor weight with a tumor growth inhibition rate of 58.9 %.

Related Protocols :

Chemical Information

Molecular Weight 854.78
Formula C₃₈H₂₇Cl₅N₂O₂PRh
SMILES

Cl[Rh]1([P](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)OC5=C6C(C=CC(C)=[N]61)=C(Cl)C=C5Cl.[2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang XQ, et al. Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways. Eur J Med Chem. 2024 Jun 5;272:116478. [Content Brief]

Hot Topics

Type:

All

Sort by:

Most Recent

Topics Mitophagy: A Central Target in Neurodegenerative Diseases
Mitophagy is a selective form of autophagy that eliminates damaged or dysfunctional mitochondria and thereby preserves mitochondrial quality control, cellular homeostasis, and neuronal survival.

2026-06-18
Topics When Mitophagy Becomes An Innate Immune Checkpoint
Mitophagy becomes an innate immune checkpoint when selective autophagic removal of damaged mitochondria regulates the availability of mitochondrial danger signals that activate innate immune pathways.

2026-06-18

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote