Anticancer agent 227
Anticancer agent 227 (compound YNU-1c) is a potent anticancer agent. Anticancer agent 227 shows antiproliferative activity. Anticancer agent 227 induces apoptosis and mitophagy.
For research use only. We do not sell to patients.
- Formula: C38H27Cl5N2O2PRh
- Molecular Weight:854.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Anticancer agent 227 (compound YNU-1c) (0-50 µM; 48 h) shows antiproliferative activity with IC50s of 0.19, 0.13, >50 µM for HepG2, HCC1806, HL-7702 cells, respectively[1].
Anticancer agent 227 (0.13 µM; 48 h) induces apoptosis by increasing the expression of cytochrome c and cleaved caspase-3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2, HCC1806, HL-7702, SF1, SF2 cells
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Concentration:0-50 μM
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Incubation Time:48 h
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Result:Showed antiproliferative activity with IC50s of 0.19, 0.13, >50, >384.6, >263.2 μM for HepG2, HCC1806, HL-7702, SF1, SF2 cells, respectively.
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Cell Line:HCC1806 cells
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Concentration:0.13 µM
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Incubation Time:48 h
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Result:Upregulated the expression of cytochrome c and cleaved caspase-3.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c nude mice (HCC1806 cells)[1]
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Dosage:5 mg/kg
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Administration:I.p.; every 2 days for 21 days
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Result:Effectively inhibited HCC1806 tumor growth, reduced tumor weight with a tumor growth inhibition rate of 58.9 %.
Chemical Information
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Molecular Weight 854.78
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Formula C38H27Cl5N2O2PRh
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SMILES
Cl[Rh]1([P](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)OC5=C6C(C=CC(C)=[N]61)=C(Cl)C=C5Cl.[2]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 227 Related Classifications
HY-163619 Related Classifications
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