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Cat. No.: HY-150968

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Antiproliferative agent-11

Antiproliferative agent-11 (compound 7) is an antiproliferative and selective Ruthenium(II)-Tris-pyrazolylmethane complex. Antiproliferative agent-11 shows antiproliferative activity towards MCF-7, HeLa, 518A2, HCT116 and RD with IC₅₀s of 6, 10, 6.8, 6.7 and 6 μM, respectively. Antiproliferative agent-11 can be used for the research of cancer.

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화학식: C₃₁H₃₄Cl₂N₆O₃P₂Ru
분자량:772.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (285 KB)

Antiproliferative agent-11 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: 6 μM (MCF-7), 6 μM (RD), 6.7 μM (HCT116), 6.8 μM (518A2) , 10 μM (HeLa)^[1]

In Vitro

Antiproliferative agent-11 (0-100 μM; 72 h) exhibits antiproliferative activity to MCF-7, HeLa, 518A2, HCT116 and RD^[1].
Antiproliferative agent-11 (26.8 μM; 24 h) induces apoptosis in HCT116 cells^[1].
Antiproliferative agent-11 (10-26.8 μM; 72 h) promotes HCT116 cells death by a mitochondria-dependent mechanism^[1].
Antiproliferative agent-11 (0-50 μM; 24 h) inhibits HCT116 cells under 3D cell culture conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7, HeLa, 518A2, HCT116, RD and MRC5pd30
Concentration:

0-100 μM
Incubation Time:

72 hours
Result:

Showed selectively antiproliferative activity to MCF-7, HeLa, 518A2, HCT116 and RD with IC₅₀s of 6, 10, 6.8, 6.7 and 6 μM, respectively.

Apoptosis Analysis^[1]

Cell Line:

HCT116
Concentration:

26.8 μM
Incubation Time:

24 hours
Result:

Induced apoptosis in HCT116 to achieve antiproliferative activity.

Cell Viability Assay^[1]

Cell Line:

HCT116
Concentration:

10, 12.4 and 26.8 μM
Incubation Time:

72 hours
Result:

Reduced mitochondrial membrane potential and generated mitochondrial depolarization.

Cell Proliferation Assay^[1]

Cell Line:

HCT116
Concentration:

0-50 μM
Incubation Time:

5 hours
Result:

Inhibited HCT116 with an IC₅₀ value of 12.2 μM under 3D cell culture conditions.

Chemical Information

분자량 772.56
화학식 C₃₁H₃₄Cl₂N₆O₃P₂Ru
SMILES

[H]c12n3cccn3[Ru+](n4n2ccc4)(Cl)([P](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)([P](OC)(OC)OC)n8n1ccc8.[Cl-]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cervinka J, et al. Ruthenium(II)-Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis. J Med Chem. 2022 Aug 1. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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