2. Apoptosis
  3. Apoptosis
  4. Antiproliferative agent-11

Antiproliferative agent-11 (compound 7) is an antiproliferative and selective Ruthenium(II)-Tris-pyrazolylmethane complex. Antiproliferative agent-11 shows antiproliferative activity towards MCF-7, HeLa, 518A2, HCT116 and RD with IC50s of 6, 10, 6.8, 6.7 and 6 μM, respectively. Antiproliferative agent-11 can be used for the research of cancer.

For research use only. We do not sell to patients.

Antiproliferative agent-11 Chemical Structure

Antiproliferative agent-11 Chemical Structure

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Antiproliferative agent-11 Related Antibodies

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Description

Antiproliferative agent-11 (compound 7) is an antiproliferative and selective Ruthenium(II)-Tris-pyrazolylmethane complex. Antiproliferative agent-11 shows antiproliferative activity towards MCF-7, HeLa, 518A2, HCT116 and RD with IC50s of 6, 10, 6.8, 6.7 and 6 μM, respectively. Antiproliferative agent-11 can be used for the research of cancer[1].

IC50 & Target

IC50: 6 μM (MCF-7), 6 μM (RD), 6.7 μM (HCT116), 6.8 μM (518A2) , 10 μM (HeLa)[1]
In Vitro

Antiproliferative agent-11 (0-100 μM; 72 h) exhibits antiproliferative activity to MCF-7, HeLa, 518A2, HCT116 and RD[1].
Antiproliferative agent-11 (26.8 μM; 24 h) induces apoptosis in HCT116 cells[1].
Antiproliferative agent-11 (10-26.8 μM; 72 h) promotes HCT116 cells death by a mitochondria-dependent mechanism[1].
Antiproliferative agent-11 (0-50 μM; 24 h) inhibits HCT116 cells under 3D cell culture conditions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiproliferative agent-11 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7, HeLa, 518A2, HCT116, RD and MRC5pd30
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Showed selectively antiproliferative activity to MCF-7, HeLa, 518A2, HCT116 and RD with IC50s of 6, 10, 6.8, 6.7 and 6 μM, respectively.

Apoptosis Analysis[1]

Cell Line: HCT116
Concentration: 26.8 μM
Incubation Time: 24 hours
Result: Induced apoptosis in HCT116 to achieve antiproliferative activity.

Cell Viability Assay[1]

Cell Line: HCT116
Concentration: 10, 12.4 and 26.8 μM
Incubation Time: 72 hours
Result: Reduced mitochondrial membrane potential and generated mitochondrial depolarization.

Cell Proliferation Assay[1]

Cell Line: HCT116
Concentration: 0-50 μM
Incubation Time: 5 hours
Result: Inhibited HCT116 with an IC50 value of 12.2 μM under 3D cell culture conditions.
Molecular Weight

772.56

Formula

C31H34Cl2N6O3P2Ru
SMILES

[H]c12n3cccn3[Ru+](n4n2ccc4)(Cl)([P](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)([P](OC)(OC)OC)n8n1ccc8.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiproliferative agent-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-11Antiproliferative agent11Antiproliferative agent 11Apoptosisantiproliferativecalcium homeostasiscancer3D cell cultureInhibitorinhibitorinhibit

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