Antiproliferative agent-11
Antiproliferative agent-11 (compound 7) is an antiproliferative and selective Ruthenium(II)-Tris-pyrazolylmethane complex. Antiproliferative agent-11 shows antiproliferative activity towards MCF-7, HeLa, 518A2, HCT116 and RD with IC50s of 6, 10, 6.8, 6.7 and 6 μM, respectively. Antiproliferative agent-11 can be used for the research of cancer.
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- Formule: C31H34Cl2N6O3P2Ru
- Masse moléculaire:772.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
IC50 & Target
IC50: 6 μM (MCF-7), 6 μM (RD), 6.7 μM (HCT116), 6.8 μM (518A2) , 10 μM (HeLa)[1]
In Vitro
Antiproliferative agent-11 (0-100 μM; 72 h) exhibits antiproliferative activity to MCF-7, HeLa, 518A2, HCT116 and RD[1]. Antiproliferative agent-11 (26.8 μM; 24 h) induces apoptosis in HCT116 cells[1]. Antiproliferative agent-11 (10-26.8 μM; 72 h) promotes HCT116 cells death by a mitochondria-dependent mechanism[1]. Antiproliferative agent-11 (0-50 μM; 24 h) inhibits HCT116 cells under 3D cell culture conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, HeLa, 518A2, HCT116, RD and MRC5pd30
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Concentration:0-100 μM
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Incubation Time:72 hours
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Result:Showed selectively antiproliferative activity to MCF-7, HeLa, 518A2, HCT116 and RD with IC50s of 6, 10, 6.8, 6.7 and 6 μM, respectively.
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Cell Line:HCT116
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Concentration:26.8 μM
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Incubation Time:24 hours
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Result:Induced apoptosis in HCT116 to achieve antiproliferative activity.
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Cell Line:HCT116
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Concentration:10, 12.4 and 26.8 μM
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Incubation Time:72 hours
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Result:Reduced mitochondrial membrane potential and generated mitochondrial depolarization.
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Cell Line:HCT116
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Concentration:0-50 μM
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Incubation Time:5 hours
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Result:Inhibited HCT116 with an IC50 value of 12.2 μM under 3D cell culture conditions.
Chemical Information
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Masse moléculaire 772.56
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Formule C31H34Cl2N6O3P2Ru
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SMILES
[H]c12n3cccn3[Ru+](n4n2ccc4)(Cl)([P](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)([P](OC)(OC)OC)n8n1ccc8.[Cl-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (285 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiproliferative agent-11 Related Classifications
HY-150968 Related Classifications
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