Antiproliferative agent-12
Antiproliferative agent-10 (compound 1) is an anti-tumour ruthenium(II)-tris-pyrazolylmethane complex that inhibits the growth of cancer cells by inhibiting mitochondrial calcium uptake.
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- CAS 番号: 362589-95-5
- 分子式: C46H40Cl2N6P2Ru
- 分子量:910.79
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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Help & FAQs
生物活性
製品説明
体外実験
Antiproliferative agent-10 (compound 1) (1.5-5.8 μM, 72 h) has significantly anti-cancer cell proliferative activity and effectively induces apoptosis in HCT116 cells[1].
Antiproliferative agent-10 (15 μM, 24 h) shows HCT116 cell survival rates of 93% to 97% and ruthenium content of cell was 145.1 ng/106 cells, so that it can accumulate efficiently in the cells and promote their biological activity[1].
Antiproliferative agent-10 (3-10 μM, 5 h) can cause mitochondrial depolarization in a concentration-dependent manner and inhibit mitochondrial calcium uptake[1].
Antiproliferative agent-10 can inhibit the formation and growth of spheroids of HCT116 cells with an IC50 value of 2.5 μM, approximately 18-fold more effective than cisplatin and almost completely disintegrate of the spheroids[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 (breast), HeLa (cervical), 518A2 (melanoma), HCT116 (colon), RD (rhabdomyosarcoma)
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Concentration:1.5-5.8 μM
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Incubation Time:72 hours
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Result:Inhibited the proliferation of MCF-7, HeLa, 518A2, HCT116 and RD with the IC50 values of 2.4, 4, 2.6, 1.5 and 2.2 μM, respectively.
化学情報
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CAS 番号 362589-95-5
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分子量 910.79
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分子式 C46H40Cl2N6P2Ru
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SMILES
[H]c12n3cccn3[Ru+](n4n2ccc4)(Cl)([P](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)([P](C8=CC=CC=C8)(C9=CC=CC=C9)C%10=CC=CC=C%10)n%11n1ccc%11.[Cl-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antiproliferative agent-12 関連分類
HY-150969 関連分類
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