Antiproliferative agent-12
Antiproliferative agent-10 (compound 1) is an anti-tumour ruthenium(II)-tris-pyrazolylmethane complex that inhibits the growth of cancer cells by inhibiting mitochondrial calcium uptake.
For research use only. We do not sell to patients.
- Formula: C46H40Cl2N6P2Ru
- Molecular Weight:910.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antiproliferative agent-10 (compound 1) (1.5-5.8 μM, 72 h) has significantly anti-cancer cell proliferative activity and effectively induces apoptosis in HCT116 cells[1].
Antiproliferative agent-10 (15 μM, 24 h) shows HCT116 cell survival rates of 93% to 97% and ruthenium content of cell was 145.1 ng/106 cells, so that it can accumulate efficiently in the cells and promote their biological activity[1].
Antiproliferative agent-10 (3-10 μM, 5 h) can cause mitochondrial depolarization in a concentration-dependent manner and inhibit mitochondrial calcium uptake[1].
Antiproliferative agent-10 can inhibit the formation and growth of spheroids of HCT116 cells with an IC50 value of 2.5 μM, approximately 18-fold more effective than cisplatin and almost completely disintegrate of the spheroids[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 (breast), HeLa (cervical), 518A2 (melanoma), HCT116 (colon), RD (rhabdomyosarcoma)
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Concentration:1.5-5.8 μM
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Incubation Time:72 hours
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Result:Inhibited the proliferation of MCF-7, HeLa, 518A2, HCT116 and RD with the IC50 values of 2.4, 4, 2.6, 1.5 and 2.2 μM, respectively.
Chemical Information
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Molecular Weight 910.79
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Formula C46H40Cl2N6P2Ru
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SMILES
[H]c12n3cccn3[Ru+](n4n2ccc4)(Cl)([P](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)([P](C8=CC=CC=C8)(C9=CC=CC=C9)C%10=CC=CC=C%10)n%11n1ccc%11.[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiproliferative agent-12 Related Classifications
HY-150969 Related Classifications
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