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Antitubercular agent-60

Antitubercular agent-60 is an orally active antitubercular agent. Antitubercular agent-60 targets the arabinogalactan biosynthesis pathway in Mycobacterium tuberculosis. Antitubercular agent-60 can be used for the research of tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 1356814-93-1
Formula: C₁₉H₂₉N₅
Molecular Weight:327.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antitubercular agent-60 Chemical Structure

CAS No.: 1356814-93-1

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Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

Antitubercular agent-60 (compound 1) inhibits growth of Mycobacterium tuberculosis H37Rv with an MIC of 3.2 μM in 7H9/DPPC/CAS/Tx media and 3.6 μM in 7H9/GLU/CAS/Tx media^[1].
Antitubercular agent-60 disrupts cell wall biosynthesis in Mycobacterium tuberculosis PiniB-LUX reporter strains, as measured by a robust bioluminescence signal^[1].
Antitubercular agent-60 (0.125×-0.625× MIC) targets the arabinogalactan biosynthesis pathway in Mycobacterium tuberculosis, as reduced expression of embA, embB, embC, or ubiA sensitizes strains to growth inhibition^[1].
Antitubercular agent-60 has reduced growth inhibition activity against Mycobacterium tuberculosis H37Rv when the embCAB operon is overexpressed, confirming targeting of the arabinogalactan biosynthesis pathway^[1].
Antitubercular agent-60 (10 μM; 7 days) reduces Mycobacterium tuberculosis H37Rv burden in J774 macrophages, with activity superior to 1 μM Rifampicin (HY-B0272) after 7 days of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	F	T_1/2	CL	V_dss
Mice^[1]	2.5 mg/kg	i.v.	/	/	/	1.6 h	91 mL/min/kg	8.1 L/kg
Mice^[1]	10 mg/kg	p.o.	157 ng/mL	60 min	23 %	/	/	/

Chemical Information

CAS No. 1356814-93-1
Molecular Weight 327.47
Formula C₁₉H₂₉N₅
SMILES

CC(C1=NNC=C1CNC2CCN(CC3=NC=CC=C3)CC2)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Naylor C, et al. Identification and Evaluation of dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis. bioRxiv [Preprint]. 2026 Jan 30:2026.01.30.702510.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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