2. Anti-infection
  3. Bacterial
  4. Antitubercular agent-60

Antitubercular agent-60 is an orally active antitubercular agent. Antitubercular agent-60 targets the arabinogalactan biosynthesis pathway in Mycobacterium tuberculosis. Antitubercular agent-60 can be used for the research of tuberculosis.

For research use only. We do not sell to patients.

Antitubercular agent-60

Antitubercular agent-60 Chemical Structure

CAS No. : 1356814-93-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Antitubercular agent-60 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Antitubercular agent-60 is an orally active antitubercular agent. Antitubercular agent-60 targets the arabinogalactan biosynthesis pathway in Mycobacterium tuberculosis. Antitubercular agent-60 can be used for the research of tuberculosis[1].

In Vitro

Antitubercular agent-60 (compound 1) inhibits growth of Mycobacterium tuberculosis H37Rv with an MIC of 3.2 μM in 7H9/DPPC/CAS/Tx media and 3.6 μM in 7H9/GLU/CAS/Tx media[1].
Antitubercular agent-60 disrupts cell wall biosynthesis in Mycobacterium tuberculosis PiniB-LUX reporter strains, as measured by a robust bioluminescence signal[1].
Antitubercular agent-60 (0.125×-0.625× MIC) targets the arabinogalactan biosynthesis pathway in Mycobacterium tuberculosis, as reduced expression of embA, embB, embC, or ubiA sensitizes strains to growth inhibition[1].
Antitubercular agent-60 has reduced growth inhibition activity against Mycobacterium tuberculosis H37Rv when the embCAB operon is overexpressed, confirming targeting of the arabinogalactan biosynthesis pathway[1].
Antitubercular agent-60 (10 μM; 7 days) reduces Mycobacterium tuberculosis H37Rv burden in J774 macrophages, with activity superior to 1 μM Rifampicin (HY-B0272) after 7 days of treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitubercular agent-60 Related Antibodies
Parmacokinetics
Species Dose Route Cmax Tmax F T1/2 CL Vdss
Mice[1] 2.5 mg/kg i.v. / / / 1.6 h 91 mL/min/kg 8.1 L/kg
Mice[1] 10 mg/kg p.o. 157 ng/mL 60 min 23 % / / /
Molecular Weight

327.47

Formula

C19H29N5
CAS No.
SMILES

CC(C1=NNC=C1CNC2CCN(CC3=NC=CC=C3)CC2)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Antitubercular agent-60 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitubercular agent-601356814-93-1Antitubercular agent60Antitubercular agent 60BacterialDprE1HepG2 cellsethambutol-resistant Mycobacterium tuberculosis clinical isolatesMycobacterium tuberculosisPks13InhAMmpL3arabinogalactan biosynthesis pathwayMycobacterium tuberculosis H37RvJ774 macrophagesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Antitubercular agent-60
Cat. No.:
HY-183998
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.