2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. ASP6918

ASP6918 is a potent and orally active KRAS G12C inhibitor with an IC50 value of 0.028 µM. ASP6918 inhibits cell growth. ASP6918 shows antitumor activity.

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ASP6918

ASP6918 화학구조

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ASP6918 Related Antibodies

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제품 설명

ASP6918 is a potent and orally active KRAS G12C inhibitor with an IC50 value of 0.028 µM. ASP6918 inhibits cell growth. ASP6918 shows antitumor activity[1].

IC50 & Target[1]

KRas G12C

0.028 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
NCI-H1373 IC50
0.006 μM
Compound: 29a; ASP6918
Cytotoxicity against KRAS G12C mutant positive human NCI-H1373 cells assessed as inhibition of cell growth incubated for 6 days by Celltiter-Glo 2.0 assay
Cytotoxicity against KRAS G12C mutant positive human NCI-H1373 cells assessed as inhibition of cell growth incubated for 6 days by Celltiter-Glo 2.0 assay
[PMID: 38176113]
NCI-H1373 IC50
0.008 μM
Compound: 28b
Cytotoxicity against KRAS G12C mutant positive human NCI-H1373 cells assessed as inhibition of cell growth incubated for 6 days by Celltiter-Glo 2.0 assay
Cytotoxicity against KRAS G12C mutant positive human NCI-H1373 cells assessed as inhibition of cell growth incubated for 6 days by Celltiter-Glo 2.0 assay
[PMID: 38176113]
In Vitro

ASP6918 (compound 29a) (6 days) inhibits cell growth with an IC50 value of 0.0061 µM for NCI-H1373 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ASP6918 Related Antibodies

Cell Viability Assay[1]

Cell Line: NCI-H1373 cells
Concentration:
Incubation Time: 6 days
Result: Inhibited cell growth with an IC50 value of 0.0061 µM.
In Vivo

ASP6918 (10, 20, 40, 60 mg/kg; p.o.; daily for 13 days) shows antitumor activity in NCI-H1373 xenograft mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old male nude mice (NCI-H1373 xenograft mouse model)[1]
Dosage: 10, 20, 40, 60 mg/kg
Administration: Oral, daily for 13 days
Result: Inhibited of tumor growth with tumor growth inhibition (TGI) rate of 27%, 68%, 49%, 73% at 10, 20, 40, 60 mg/kg.
분자량

621.77

화학식

C36H43N7O3
SMILES

C=CC1=CC2=C(N=C(OC3CCN(C)CC3)N=C2N4CCC5(CN(C(C=C)=O)C5)CC4)C(OCC)=[C@]1[C@]6=C(C)C=CC7=C6C=NN7
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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ASP6918 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASP6918ASP 6918ASP-6918RasNCI-H1373 cellsoral activityantitumorInhibitorinhibitorinhibit

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상품명:
ASP6918
Cat. No.:
HY-162249
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