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Art. -Nr.: HY-149854

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AB21

AB21 is a potent and selective S1R antagonist with K_is of 13, 102 nM for S1R and S2R. AB21 has the effect of reducing mechanical hypersensitivity.

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CAS. Nr.: 3026677-23-3
Formel: C₂₃H₂₈N₂O
Molecular Weight:348.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AB21 Chemical Structure

CAS. Nr.: 3026677-23-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AB21 is a potent and selective S1R antagonist with K_is of 13, 102 nM for S1R and S2R. AB21 has the effect of reducing mechanical hypersensitivity^[1].

IC₅₀ & Target

^[1]

Sigma 1 Receptor

13 nM (Ki)

Sigma 2 Receptor

102 nM (Ki)

Alle Sigma Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

AB21 shows K_is of 12 nM and 14 nM with or without Phenytoin in the S1R Radioligand Binding Assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AB21 (20 mg/kg, s.c., administered 30 min before the injection of Capsaicin (HY-10448)) reverses mechanical allodyniain in Capsaicin (HY-B0448)-induced pain model, and exhibits higher potency than BD1063 dhydrochloride (HY-18101A)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Capsaicin-induced mechanical hypersensitivity model in mice^[1]
Dosage:

20 mg/kg
Administration:

Subcutaneous injection (s.c.); administered 30 min before the injection of capsaicin
Result:

Result: Showed complete reversal of the mechanical hypersensitivity reaction and the dose administered was half that of BD-1063 (40 mg/kg).

Chemical Information

CAS. Nr. 3026677-23-3
Molecular Weight 348.48
Formel C₂₃H₂₈N₂O
SMILES

O=C(N(CC1)CCC21CN(CCC3=CC=CC=C3)C2)CC4=CC=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Dichiara M, et al. Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands. ACS Chem Neurosci. 2023 May 17;14(10):1845-1858. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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