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Art. -Nr.: HY-182057

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ALK degrader 4

ALK degrader 4 is a ALK HyT degrader with an IC₅₀ of 0.74 nM. ALK degrader 4 inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes ALK to form a partially unfolded conformation, and induces proteasomal degradation of ALK. ALK degrader 4 inhibits cancer cell proliferation. ALK degrader 4 can be used in research related to non-small cell lung cancer (ALK ligand: Brigatinib (HY-12857); hydrophobic tag: Norbornene (HY-W013021)).

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CAS. Nr.: 3111011-76-5
Formel: C₃₆H₄₅ClN₇O₃P
Molecular Weight:690.21

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ALK degrader 4 Chemical Structure

CAS. Nr.: 3111011-76-5

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

ALK degrader 4 (compound B7) potently inhibits the proliferation of H3122 cells over 7 days, with an IC₅₀ value of 68.98 nM^[1].
ALK degrader 4 (0.05-2 μM; 24 h) induces concentration-dependent degradation of ALK protein in H3122 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

H3122 cells
Concentration:

0.05, 0.1, 0.5, 1, 2 μM
Incubation Time:

24 h
Result:

Reduced ALK protein levels in H3122 cells in a concentration-dependent manner.

Chemical Information

CAS. Nr. 3111011-76-5
Molecular Weight 690.21
Formel C₃₆H₄₅ClN₇O₃P
SMILES

CP(C)(C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCC(N5CCN(C(C6C(C7)C=CC7C6)=O)CC5)CC4)C=C3OC)=NC=C2Cl)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Chu D, et al. Polyhedral alkanes as hydrophobic tags for dual-functional ALK inhibitor-degrader. Bioorg Chem. 2026;173:109674. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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