country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-189125

Copy Link Print Information

Anticancer agent 360

Anticancer agent 360 is a broad-spectrum antibacterial agent. Anticancer agent 360 binds to the ATP pocket of the GyrB subunit of DNA gyrase via an Arg84 salt bridge, interfering with gyrase-dependent DNA supercoiling. Anticancer agent 360 disrupts bacterial biofilms and inhibits the metabolic activity of respiratory chain dehydrogenases. Anticancer agent 360 exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and fungal strains. Anticancer agent 360 exerts selective cytotoxicity against liver cancer cells. Anticancer agent 360 can be used in studies related to bacterial infections and liver cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₃H₁₃N₃O₅
Molecular Weight:411.37

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 360 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

Bacterial InfectionFungal InfectionAnti-cancer

Bacterial Infection

Fungal Infection

Anticancer agent 360 (compound 13) (2-64 µg/mL; 24-30 h) exhibits potent and broad-spectrum antimicrobial activity against all tested reference bacterial and fungal strains, with its MIC against Staphylococcus aureus ATCC 9144 as low as 2 µg/mL^[1].

Anti-cancer

Anticancer agent 360 (5-100 µg/mL; 48 h) reduces the viability of HepG2 cells at high concentrations, exhibiting selective cytotoxic activity against HepG2 hepatocellular carcinoma cells^[1].

Bacterial Infection

Anticancer agent 360 (0.25-0.8 MIC; 2-4 h) eliminates preformed P. aeruginosa ATCC 27853 biofilms in a dose- and time-dependent manner^[1].
Antineoplastic agent 360 (0.25-0.8 MIC; 2-4 h) effectively inhibits the activity of respiratory chain dehydrogenase in P. aeruginosa ATCC 27853 biofilms, and this effect exhibits a concentration- and time-dependent manner in vitro^[1].
Anticancer agent 360 exhibits strong binding affinity for the ATP-binding pockets of DNA gyrase from both E. coli and S. aureus, and can form stable salt bridge interactions with key active-site residues, with its relative affinity for the S. aureus enzyme being higher than that of the co-crystallized ligand^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human hepatocellular carcinoma HepG2 cells
Concentration:

5 and 100 µg/mL
Incubation Time:

48 h
Result:

Reduced HepG2 cell viability to 85% at 5 µg/mL.
Reduced HepG2 cell viability to 40% at 100 µg/mL.

Related Protocols :

Chemical Information

Molecular Weight 411.37
Formel C₂₃H₁₃N₃O₅
SMILES

O=C1OC(C2=CC=CC=C2)=NC3=C1C(C4=CC=CO4)=CC(C5=CC=C([N+]([O-])=O)C=C5)=N3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Hassan AMA, et al. Synthesis and molecular docking of novel pyrazole, pyrimidine, and pyridine derivatives as potent antimicrobial, antibiofilm, and anticancer agents. Scientific reports. 2026 Aug 08;16(1):24543.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen