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Art. -Nr.: HY-141882

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DC-LC3in-D5

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC₅₀ of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or combination researchs in cancer through inhibiting autophagy.

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Reinheit: 98.62%
CAS. Nr.: 2868312-73-4
Formel: C₁₉H₂₂Cl₂N₂O₃
Molecular Weight:397.30

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

DC-LC3in-D5 Chemical Structure

CAS. Nr.: 2868312-73-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

DC-LC3in-D5 demonstrates high selectivity to LC3A/B in the proteome. DC-LC3in-D5 exhibits a potent covalent reactivity and selectivity to LC3A/B in HeLa cells^[1].
Treatment of HeLa cells with DC-LC3in-D5 (3-30 μM) results in disruption of LC3B lipidation, inhibition of autophagic vesicle formation, and accumulation of p62^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HeLa cells
Concentration:

3, 10, 30 μM
Incubation Time:

16 hours
Result:

Pre-treated accumulated significant more p62 than DMSO-treated control samples. Attenuated LC3-I/II lipidation in cells exposed to autophagy inducing conditions.

Chemical Information

CAS. Nr. 2868312-73-4
Appearance Solid
Molecular Weight 397.30
Formel C₁₉H₂₂Cl₂N₂O₃
Color White to light yellow
SMILES

O=C1/C(C(CC(C2=C(Cl)C(Cl)=CC=C2)C1)=O)=C/NCCN3CCOCC3
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Cell

Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs. [Abstract]

2026 Apr 2;189(7):1923-1941.e26. PMID: 41785850

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 35.71 mg/mL (89.88 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5170 mL

12.5849 mL

25.1699 mL

5 mM

0.5034 mL

2.5170 mL

5.0340 mL

10 mM

0.2517 mL

1.2585 mL

2.5170 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shijie Fan, et al. Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5170 mL	12.5849 mL	25.1699 mL	62.9247 mL
	5 mM	0.5034 mL	2.5170 mL	5.0340 mL	12.5849 mL
	10 mM	0.2517 mL	1.2585 mL	2.5170 mL	6.2925 mL
	15 mM	0.1678 mL	0.8390 mL	1.6780 mL	4.1950 mL
	20 mM	0.1258 mL	0.6292 mL	1.2585 mL	3.1462 mL
	25 mM	0.1007 mL	0.5034 mL	1.0068 mL	2.5170 mL
	30 mM	0.0839 mL	0.4195 mL	0.8390 mL	2.0975 mL
	40 mM	0.0629 mL	0.3146 mL	0.6292 mL	1.5731 mL
	50 mM	0.0503 mL	0.2517 mL	0.5034 mL	1.2585 mL
	60 mM	0.0419 mL	0.2097 mL	0.4195 mL	1.0487 mL
	80 mM	0.0315 mL	0.1573 mL	0.3146 mL	0.7866 mL

Keywords

DC-LC3in-D5

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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DC-LC3in-D5

Anti-Infection Compound Library

Autophagy Compound Library

Covalent Screening Library

Cysteine Targeted Covalent Library

Cell Death Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Anti-Brain Cancer Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) DC-LC3in-D5

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DC-LC3in-D5

Anti-Infection Compound Library

Autophagy Compound Library

Covalent Screening Library

Cysteine Targeted Covalent Library

Cell Death Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Anti-Brain Cancer Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) DC-LC3in-D5

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DC-LC3in-D5 Related Classifications

HY-141882 Related Classifications