FINDY
FINDY is a folding intermediate-selective inhibitor of DYRK1A. FINDY can inhibit Ser97 autophosphorylation with an IC50 value of 35 μM. FINDY can be used for the research of neurological disorder. FINDY is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1507367-37-4
- Formel: C16H17NO2S2Si
- Molecular Weight:347.53
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-142295
GNF2133DYRK1A Inhibitor -
HY-12277
AZ191DYRK1B Inhibitor -
HY-108476
INDYDyrk1A And Dyrk1B Inhibitor -
HY-105309
GSK-626616DYRK3 Inhibitor -
HY-15838
ID-8DYRK Inhibitor -
HY-100464
tBIDHIPK2 Inhibitor -
HY-U00439A
Protein kinase inhibitor 1 hydrochloride -
HY-13455
LDN-192960Haspin Inhibitor -
HY-12838
RO5454948Dyrk Inhibitor -
HY-117391
AZ-Dyrk1B-33Dyrk1B Kinase Inhibitor -
HY-128439
BT173HIPK2 Inhibitor -
HY-146221
Dyrk1A-IN-5DYRK1A Inhibitor
Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 35 μM (Ser97 autophosphorylation)[1]
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HT-22 | IC50 |
64.8 μM
Compound: 41; FINDY
|
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
|
[PMID: 36876904] |
In Vitro
FINDY (Compound 1) inhibits Ser97 autophosphorylation with an IC50 value of 35 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS. Nr. 1507367-37-4
-
Molecular Weight 347.53
-
Formel C16H17NO2S2Si
-
SMILES
C[Si](C)(C)C#CC1=C(C=CC(/C=C2SC(NC\2=O)=S)=C1)OC
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
-
EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
FINDY Related Classifications
HY-152183 Related Classifications
Powered by Bioz