PASK - PAS domain containing serine/threonine kinase Gene

Also Known as STK37; PASKIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23178

About PASK

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,106,099-241,150,347 (from NCBI)

This gene has 16 transcripts (splice variants) and 198 orthologues. Broad expression in testis (RPKM 7.9), lymph node (RPKM 6.8) and 21 other tissues.

Summary

This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of Insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

PASK Products (5)

mRNA Protein Name
NM_001252119.2 NP_001239048.1 PAS domain-containing serine/threonine-protein kinase isoform 1
NM_001252120.2 NP_001239049.1 PAS domain-containing serine/threonine-protein kinase isoform 2
NM_001252122.2 NP_001239051.1 PAS domain-containing serine/threonine-protein kinase isoform 3
NM_001252124.2 NP_001239053.1 PAS domain-containing serine/threonine-protein kinase isoform 4
NM_015148.4 NP_055963.2 PAS domain-containing serine/threonine-protein kinase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
21418524 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16275910 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
16275910 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of glycogen biosynthetic process IDA
IDA: Inferred from direct assay
16275910 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
20943661 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
16275910 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17595531 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17595531 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PASK Protein Structure

PAS_9

PAS_9: PAS domain (133 - 224)

Pkinase

Pkinase: Protein kinase domain (999 - 1251)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1323 a.a.
Protein Preferred Names Protein Names

PAS domain-containing serine/threonine-protein kinase

  • per-arnt-sim (PAS) domain kinase

PASK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PASK Q96RG2 RPS6 Homo sapiens P62753
Protein Kinase Assay
21418524
Intra
PASK Q96RG2 CREB1 Homo sapiens P16220
Protein Kinase Assay
21418524
Intra
PASK Q96RG2 PHKB Homo sapiens Q93100
Protein Kinase Assay
21418524
Cross
PASK Q96RG2 CACNA1S Oryctolagus cuniculus P07293
Peptide Array
21418524
Cross
PASK Q96RG2 TNNI3 Oryctolagus cuniculus P02646
Peptide Array
21418524
Cross
PASK Q96RG2 GFAP Bos taurus Q28115
Peptide Array
21418524
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Niemann-Pick Disease, Type C1

  • Niemann-Pick Disease, Type C

  • NPC1

  • Niemann-Pick Disease, Type D

  • Niemann-Pick Disease Type C1

  • Niemann-Pick Disease With Cholesterol Esterification Block

  • Niemann-Pick Disease, Subacute Juvenile Form

  • Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia

  • Npc

  • Niemann-Pick Disease, Chronic Neuronopathic Form

  • Niemann-Pick Disease Without Sphingomyelinase Deficiency

  • Niemann-Pick Disease Type C

  • Niemann-Pick Disease Type D

  • Niemann-Pick C1 Disease

  • Niemann-Pick Disease C1

  • Niemann-Pick Disease Chronic Neuronopathic Form

  • Niemann-Pick Disease Nova Scotian Type

  • Niemann-Pick Disease Subacute Juvenile Form

  • Niemann-Pick Disease Type Ii

  • Niemann-Picks Disease Type C
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-129571 BioE-1115 Inhibitor 98.17% Unkown
HY-152247 DDO3711 Inhibitor / Unkown
HY-RS10078 PASK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13940 STK39 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PASK MGD MGI:2155936
Felis catus PASK VGNC VGNC:64048
Canis familiaris PASK VGNC VGNC:44270
Macaca mulatta PASK VGNC VGNC:75638
Rattus norvegicus PASK RGD RGD:1306146
Bos taurus PASK VGNC VGNC:58397
Others PASK NCBI