ACE - angiotensin I converting enzyme Gene

Also Known as Dcp1; CD143; StsRR92

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24310

About ACE

Primary_assembly 10: 90,910,316-90,931,131 forward strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 94 orthologues, 2 paralogues and is associated with 184 phenotypes. Biased expression in Lung (RPKM 989.5), Testes (RPKM 175.9) and 2 other tissues.

Summary

Enables heterocyclic compound binding activity; metallopeptidase activity; and peptidyl-dipeptidase activity. Involved in several processes, including animal organ development; negative regulation of transport; and response to corticosteroid. Located in several cellular components, including basal plasma membrane; brush border membrane; and sperm midpiece. Used to study several diseases, including artery disease (multiple); glomerulonephritis (multiple); kidney failure (multiple); lung disease (multiple); and proteinuria (multiple). Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; endomyocardial fibrosis; liver cirrhosis (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system Cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, Apr 2022]

ACE Products (1)

mRNA Protein Name
NM_012544.1 NP_036676.1 angiotensin-converting enzyme precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables heterocyclic compound binding IDA
IDA: Inferred from direct assay
7620708 RGD
enables metallopeptidase activity IMP
IMP: Inferred from mutant phenotype
11299220 RGD
enables peptidase activity IDA
IDA: Inferred from direct assay
12500972 RGD
enables peptidyl-dipeptidase activity IDA
IDA: Inferred from direct assay
8292044 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in angiogenesis involved in coronary vascular morphogenesis IMP
IMP: Inferred from mutant phenotype
22123369 RGD
involved in animal organ regeneration IMP
IMP: Inferred from mutant phenotype
22441330 RGD
involved in bradykinin catabolic process IDA
IDA: Inferred from direct assay
2172462 RGD
involved in bradykinin catabolic process IMP
IMP: Inferred from mutant phenotype
11299220 RGD
involved in cellular response to aldosterone IEP
IEP: Inferred from expression pattern
11447075 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
17626897 RGD
involved in eating behavior IMP
IMP: Inferred from mutant phenotype
19361967 RGD
involved in embryo development ending in birth or egg hatching IMP
IMP: Inferred from mutant phenotype
1784836 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
17977916 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
7977726 RGD
involved in lung alveolus development IMP
IMP: Inferred from mutant phenotype
22587910 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
7977726 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
7977726 RGD
involved in negative regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
24184594 RGD
involved in negative regulation of calcium ion import IMP
IMP: Inferred from mutant phenotype
10506486 RGD
involved in peptide catabolic process IDA
IDA: Inferred from direct assay
16148611 RGD
involved in peptide metabolic process IMP
IMP: Inferred from mutant phenotype
10642323 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19301230 RGD
involved in positive regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
17161436 RGD
involved in positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
20122169 RGD
involved in positive regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
10506486 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
17161436 RGD
involved in regulation of blood pressure IDA
IDA: Inferred from direct assay
1750504 RGD
involved in regulation of smooth muscle cell migration IDA
IDA: Inferred from direct assay
1750504 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
1659346 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
14527966 RGD
involved in response to laminar fluid shear stress IEP
IEP: Inferred from expression pattern
9048650 RGD
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
19114890 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
18389998 RGD
involved in response to thyroid hormone IEP
IEP: Inferred from expression pattern
1659346 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
9495881 RGD
involved in vasoconstriction IMP
IMP: Inferred from mutant phenotype
20204775 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in basal plasma membrane IDA
IDA: Inferred from direct assay
2841539 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
2827504 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
19307186 RGD
located in sperm midpiece IDA
IDA: Inferred from direct assay
12444051 RGD
located in vesicle IDA
IDA: Inferred from direct assay
2841539 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACE Protein Structure

Peptidase_M2

Peptidase_M2: pfam01401 (45 - 628)

Peptidase_M2

Peptidase_M2: pfam01401 (649 - 1226)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1313 a.a.
Protein Preferred Names Protein Names

angiotensin-converting enzyme

  • Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme)

  • angiotensin 1 converting enzyme 1

  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

  • angiotensin I converting enzyme 1

  • angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1)

  • angiotensin-converting enzyme-like

  • dipeptidyl carboxypeptidase I

  • kininase II

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-B0331 Enalapril Inhibitor 99.96% Yes
HY-B0331A Enalapril maleate Inhibitor 99.99% Yes
HY-B0331AR Enalapril maleate (Standard) Inhibitor 99.95% Unkown
HY-B1451 Imidapril hydrochloride Inhibitor 99.91% Yes
HY-B0331B Enalapril sodium Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-123381 Gemopatrilat Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-138113 Pyrrothiogatain Inhibitor 98.61% Unkown
HY-N0217 Benzoylaconine Modulator 99.92% Unkown
HY-N5063 Plantainoside D Inhibitor 99.15% Unkown
HY-B0331AS Enalapril-d5 maleate Inhibitor 99.01% Unkown
HY-P10601 αs1-CN f(143–149) Inhibitor / Unkown
HY-19200 RB-105 Inhibitor / Unkown
HY-P11464 SARS-CoV-2 Spike receptor binding domain, RBD (371-394) / Unkown
HY-P4281 Ovotransferrin (328-332) Inhibitor / Unkown
HY-182407 CV 5975 Inhibitor / Unkown
HY-182445 FPL 66564 Inhibitor / Unkown
HY-175325 SARS-CoV-2-IN-116 Inhibitor / Unkown
HY-B0331S1 Enalapril-d3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ACE NCBI NCBI:1636