ACE - angiotensin I converting enzyme Gene
Also Known as DCP; ACE1; DCP1; CD143
Species: Homo sapiens
About ACE
This gene has 21 transcripts (splice variants), 94 orthologues, 1 paralogue and is associated with 6 phenotypes. Biased expression in small intestine (RPKM 118.5), duodenum (RPKM 76.7) and 7 other tissues.
Summary
This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms. [provided by RefSeq, Sep 2020]
ACE Products (9)
| mRNA | Protein | Name |
|---|---|---|
| NM_001382702.1 | NP_001369631.1 | angiotensin-converting enzyme isoform 6 |
| NM_001178057.2 | NP_001171528.1 | angiotensin-converting enzyme isoform 3 precursor |
| NM_152830.3 | NP_690043.1 | angiotensin-converting enzyme isoform 2 precursor |
| XM_006721737.4 | XP_006721800.3 | angiotensin-converting enzyme isoform X1 |
| NM_152831.1 | ||
| NM_001382700.1 | NP_001369629.1 | angiotensin-converting enzyme isoform 4 |
| NM_000789.4 | NP_000780.1 | angiotensin-converting enzyme isoform 1 precursor |
| NM_001382701.1 | NP_001369630.1 | angiotensin-converting enzyme isoform 5 |
| NR_168483.1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables actin binding |
IDA
IDA: Inferred from direct assay
|
16186248 | GOA |
| enables bradykinin receptor binding |
IPI
IPI: Inferred from physical interaction
|
17077303 | GOA |
| enables chloride ion binding |
IDA
IDA: Inferred from direct assay
|
11432860 | GOA |
| enables endopeptidase activity |
IDA
IDA: Inferred from direct assay
|
15283675 | GOA |
| enables exopeptidase activity |
IDA
IDA: Inferred from direct assay
|
2983326 | GOA |
| enables metallodipeptidase activity |
IDA
IDA: Inferred from direct assay
|
7961923 | GOA |
| enables metalloendopeptidase activity |
IDA
IDA: Inferred from direct assay
|
6208535 | GOA |
| enables metallopeptidase activity |
IDA
IDA: Inferred from direct assay
|
1320019 | GOA |
| enables mitogen-activated protein kinase binding |
IPI
IPI: Inferred from physical interaction
|
14615289 | GOA |
| enables mitogen-activated protein kinase kinase binding |
IPI
IPI: Inferred from physical interaction
|
14615289 | GOA |
| enables peptidase activity |
IDA
IDA: Inferred from direct assay
|
11604391 | GOA |
| enables peptidyl-dipeptidase activity |
IDA
IDA: Inferred from direct assay
|
656131 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16186248 | GOA |
| enables tripeptidyl-peptidase activity |
IDA
IDA: Inferred from direct assay
|
2983326 | GOA |
| enables zinc ion binding |
IDA
IDA: Inferred from direct assay
|
12540854 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in endosome |
IDA
IDA: Inferred from direct assay
|
17077303 | GOA |
| located in external side of plasma membrane |
IDA
IDA: Inferred from direct assay
|
9449382 | GOA |
| located in extracellular exosome |
IDA
IDA: Inferred from direct assay
|
15326289 | GOA |
| is active in extracellular space |
IDA
IDA: Inferred from direct assay
|
1668266 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
1668266 | GOA |
| located in lysosome |
IDA
IDA: Inferred from direct assay
|
11076943 | GOA |
| is active in plasma membrane |
IDA
IDA: Inferred from direct assay
|
1668266 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
16186248 | GOA |
ACE Protein Structure
Peptidase_M2: Angiotensin-converting enzyme (31 - 630)
Peptidase_M2: Angiotensin-converting enzyme (634 - 1228)
- 0
- 300
- 600
- 900
- 1200
- 1306 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
angiotensin-converting enzyme |
|
|
Recombinant ACE Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7992 | ACE/CD143 Protein, Human (His) | P12821 (L642-S1230) | ≥ 90%, as determined by reducing SDS-PAGE. |
ACE Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81084 | ACE Antibody (YA3478) | WB, IHC-P, FC | Human, Mouse |
| HY-P85413 | ACE Antibody (YA5105) | WB | Human, Mouse, Rat, Bovine |
| HY-P85520 | ACE Antibody (YA5212) | WB | Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Atrial Fibrillation |
|
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| Orthostatic Proteinuria |
|
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| Hydrocephalus |
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| Conn'S Syndrome |
|
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| Coronary Stenosis |
|
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| Severe Covid-19 |
|
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| Cardiovascular System Disease |
|
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| Exanthem |
|
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| Heart Conduction Disease |
|
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| Body Mass Index Quantitative Trait Locus 11 |
|
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| Third-Degree Atrioventricular Block |
|
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| Lingual Goiter |
|
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| Generalized Atherosclerosis |
|
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| Intermittent Claudication |
|
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| Atrial Heart Septal Defect |
|
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| Bartonellosis |
|
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| Alcohol Use Disorder |
|
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| Pericardium Disease |
|
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| Chagas Disease |
|
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| Coccidiosis |
|
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| Intermediate Uveitis |
|
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| Long Covid |
|
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| Vesicoureteral Reflux |
|
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| Behcet Syndrome |
|
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| Skin Disease |
|
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| Limb Ischemia |
|
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| Intrinsic Cardiomyopathy |
|
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| Acute Anterolateral Myocardial Infarction |
|
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| Retinal Vein Occlusion |
|
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| Acute Retrobulbar Neuritis |
|
|
| Uveoparotid Fever |
|
|
| Female Breast Nipple And Areola Cancer |
|
|
| Autosomal Dominant Polycystic Kidney Disease |
|
|
| Pyridoxine Deficiency Anemia |
|
|
| Panuveitis |
|
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| Retinal Artery Occlusion |
|
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| Uveitis |
|
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| Neurosarcoidosis |
|
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| Otosclerosis |
|
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| Extrinsic Cardiomyopathy |
|
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| Pre-Eclampsia |
|
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| Anteroseptal Myocardial Infarction |
|
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| Transient Cerebral Ischemia |
|
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| Intracranial Embolism |
|
|
| Histoplasmosis Pericarditis |
|
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| Limited Scleroderma |
|
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| Endocardium Disease |
|
|
| Obstructive Nephropathy |
|
|
| Psoriasis |
|
|
| Autonomic Nervous System Disease |
|
|
| Fuchs' Heterochromic Uveitis |
|
|
| Panic Disorder |
|
|
| Hypersensitivity Reaction Type Iv Disease |
|
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| Neuroretinitis |
|
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| Iritis |
|
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| Chronic Kidney Disease |
|
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| Miliary Tuberculosis |
|
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| Akinetopsia |
|
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| Overnutrition |
|
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| Uremia |
|
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| Endomyocardial Fibrosis |
|
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| Febrile Seizures, Familial, 5 |
|
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| Acute Orbital Inflammation |
|
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| Central Sleep Apnea |
|
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| Congestive Heart Failure |
|
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| Aortic Aneurysm |
|
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| Chronic Pyelonephritis |
|
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| Osteoporosis |
|
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| Heart Aneurysm |
|
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| Diabetes Mellitus, Ketosis-Prone |
|
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| Intracranial Hypertension |
|
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| Hereditary Angioedema |
|
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| Constipation |
|
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| Drug Allergy |
|
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| Syphilis |
|
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| Thrombophilia |
|
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| Alport Syndrome |
|
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| Urinary System Disease |
|
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| Hypertensive Heart Disease |
|
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| Right Bundle Branch Block |
|
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| Ischemia |
|
|
| Lymphoid Interstitial Pneumonia |
|
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| Hypertension, Essential |
|
|
| Hypothyroidism |
|
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| Aortic Valve Insufficiency |
|
|
| Pure Autonomic Failure |
|
|
| Hypertrophic Cardiomyopathy |
|
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| Skin Sarcoidosis |
|
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| Hypertension, Diastolic |
|
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| Glomerulonephritis |
|
|
| Scoliosis |
|
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| Ureteral Disease |
|
|
| Aortic Aneurysm, Familial Abdominal, 1 |
|
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| Optic Nerve Disease |
|
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| Granulomatous Dermatitis |
|
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| Lens Disease |
|
|
| Anomalous Left Coronary Artery From The Pulmonary Artery |
|
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| Pancytopenia |
|
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| Myopathy |
|
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| Posterior Scleritis |
|
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| Internal Hordeolum |
|
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| Diabetes Mellitus |
|
|
| Chickenpox |
|
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| Dental Caries |
|
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| Constrictive Pericarditis |
|
|
| Primary Bacterial Infectious Disease |
|
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| Sleep Apnea |
|
|
| Heart Disease |
|
|
| Mononeuropathy |
|
|
| Granulomatous Hepatitis |
|
|
| Toxocariasis |
|
|
| Hypersensitivity Reaction Type Iii Disease |
|
|
| Eye Disease |
|
|
| Pulmonary Embolism |
|
|
| Renal Hypertension |
|
|
| Chorioretinal Scar |
|
|
| Macular Dystrophy, Dominant Cystoid |
|
|
| Autonomic Neuropathy |
|
|
| Hypersensitivity Vasculitis |
|
|
| Integumentary System Disease |
|
|
| Vascular Dementia |
|
|
| Left Ventricular Noncompaction |
|
|
| Mesangial Proliferative Glomerulonephritis |
|
|
| Diabetic Autonomic Neuropathy |
|
|
| Migraine With Or Without Aura 1 |
|
|
| Granuloma Annulare |
|
|
| Conjunctival Disease |
|
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| Muscular Dystrophy |
|
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| Bronchial Disease |
|
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| Autosomal Dominant Alport Syndrome |
|
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| Cardiac Tuberculosis |
|
|
| Macular Retinal Edema |
|
|
| Oligohydramnios |
|
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| Coronary Heart Disease 1 |
|
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| Mediastinum Teratoma |
|
|
| Bipolar Disorder |
|
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| Malignant Hypertension |
|
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| Aortic Valve Disease 2 |
|
|
| Hypoaldosteronism |
|
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| Deficiency Anemia |
|
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| Polycystic Kidney Disease |
|
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| Nonobstructive Coronary Artery Disease |
|
|
| Optic Papillitis |
|
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| Choroiditis |
|
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| Pulmonary Valve Insufficiency |
|
|
| Background Diabetic Retinopathy |
|
|
| Orthostatic Intolerance |
|
|
| Hypercholesterolemia, Familial, 1 |
|
|
| Microvascular Complications Of Diabetes 5 |
|
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| Hepatopulmonary Syndrome |
|
|
| Pyelonephritis |
|
|
| Acquired Angioedema |
|
|
| Hypertrophy Of Tongue Papillae |
|
|
| Myocardial Stunning |
|
|
| Respiratory Failure |
|
|
| Papilledema |
|
|
| Mild Cognitive Impairment |
|
|
| Systolic Heart Failure |
|
|
| Left Bundle Branch Hemiblock |
|
|
| Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease |
|
|
| Dilated Cardiomyopathy |
|
|
| Cranial Nerve Palsy |
|
|
| Cardiac Arrest |
|
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| Vogt-Koyanagi-Harada Disease |
|
|
| Atherosclerosis Susceptibility |
|
|
| Pyelitis |
|
|
| Peptic Ulcer Disease |
|
|
| Urinary Tract Obstruction |
|
|
| Autoimmune Disease Of Endocrine System |
|
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| Arteriosclerosis |
|
|
| Peripheral Artery Disease |
|
|
| Scleral Disease |
|
|
| Iga Glomerulonephritis |
|
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| Hypertensive Nephropathy |
|
|
| Retinal Vascular Disease |
|
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| Acute Kidney Tubular Necrosis |
|
|
| Pericarditis |
|
|
| Glossopharyngeal Nerve Disease |
|
|
| Carotid Artery Disease |
|
|
| Speech And Communication Disorders |
|
|
| First-Degree Atrioventricular Block |
|
|
| Patent Ductus Arteriosus 1 |
|
|
| Adrenal Gland Disease |
|
|
| Critical Covid-19 |
|
|
| Mitral Valve Disease |
|
|
| Malaria |
|
|
| Sarcoidosis 1 |
|
|
| Pulmonary Artery Disease |
|
|
| Carpal Tunnel Syndrome |
|
|
| Arteries, Anomalies Of |
|
|
| Cataract |
|
|
| Mitral Valve Stenosis |
|
|
| Hepatorenal Syndrome |
|
|
| Anuria |
|
|
| Lipoid Nephrosis |
|
|
| Apnea, Obstructive Sleep |
|
|
| Angioedema |
|
|
| Myocarditis |
|
|
| Tricuspid Valve Insufficiency |
|
|
| Kaolin Pneumoconiosis |
|
|
| Kidney Hypertrophy |
|
|
| Intermediate Coronary Syndrome |
|
|
| Vein Disease |
|
|
| Skin Hemangioma |
|
|
| Fibromuscular Dysplasia |
|
|
| Pulmonary Edema |
|
|
| Bell'S Palsy |
|
|
| Renal Artery Disease |
|
|
| Angiokeratoma Of Fordyce |
|
|
| Systemic Scleroderma |
|
|
| Retinal Vasculitis |
|
|
| Attention Deficit-Hyperactivity Disorder |
|
|
| Arteriolosclerosis |
|
|
| Rheumatic Fever |
|
|
| Iridocyclitis |
|
|
| Impotence |
|
|
| Vascular Disease |
|
|
| Covid-19 |
|
|
| Silent Myocardial Infarction |
|
|
| Type 1 Diabetes Mellitus |
|
|
| Deafness, Autosomal Dominant 22 |
|
|
| Peripheral Vascular Disease |
|
|
| Peripartum Cardiomyopathy |
|
|
| Carotid Stenosis |
|
|
| Eclampsia |
|
|
| Pulmonary Hypertension |
|
|
| Hypoplastic Left Heart Syndrome |
|
|
| Mineral Metabolism Disease |
|
|
| Urticaria |
|
|
| Nervous System Disease |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Disease Of Mental Health |
|
|
| Interstitial Lung Disease 2 |
|
|
| Acute Myocardial Infarction |
|
|
| Stroke, Ischemic |
|
|
| Pars Planitis |
|
|
| Acute Cor Pulmonale |
|
|
| Granulomatous Myositis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Chorioretinitis |
|
|
| Subclavian Steal Syndrome |
|
|
| Neuropathy |
|
|
| Acute Retinal Necrosis Syndrome |
|
|
| Rapidly Progressive Glomerulonephritis |
|
|
| Microvascular Complications Of Diabetes 3 |
|
|
| Angiokeratoma |
|
|
| Berylliosis |
|
|
| Nephrosclerosis |
|
|
| Hemorrhage, Intracerebral |
|
|
| Cardiac Tamponade |
|
|
| Pulmonary Disease, Chronic Obstructive |
|
|
| Aortic Dissection |
|
|
| Cough Variant Asthma |
|
|
| Acute Kidney Failure |
|
|
| Cakut |
|
|
| Carbohydrate Metabolic Disorder |
|
|
| Cystic Kidney Disease |
|
|
| Aortic Aneurysm, Familial Thoracic 1 |
|
|
| Kidney Papillary Necrosis |
|
|
| Renovascular Hypertension |
|
|
| Fissured Tongue |
|
|
| Polycythemia |
|
|
| Renal Artery Obstruction |
|
|
| Dementia |
|
|
| C1 Inhibitor Deficiency |
|
|
| End Stage Renal Disease |
|
|
| Neurogenic Bladder |
|
|
| Thyroid Gland Disease |
|
|
| Orbital Cellulitis |
|
|
| Severe Acute Respiratory Syndrome |
|
|
| Focal Segmental Glomerulosclerosis |
|
|
| Brugada Syndrome |
|
|
| Chronic Orbital Inflammation |
|
|
| Posterior Uveitis |
|
|
| Diastolic Heart Failure |
|
|
| Conjunctival Deposit |
|
|
| Secondary Syphilis |
|
|
| Anxiety |
|
|
| Nephrotic Syndrome |
|
|
| Glucose Metabolism Disease |
|
|
| Sarcoid Meningitis |
|
|
| Amyloidosis, Hereditary, Transthyretin-Related |
|
|
| Chronic Pulmonary Heart Disease |
|
|
| Kidney Disease |
|
|
| Sleep Disorder |
|
|
| Aspiration Pneumonia |
|
|
| Middle East Respiratory Syndrome |
|
|
| Cerebrovascular Disease |
|
|
| Aortic Disease |
|
|
| Hypokalemia |
|
|
| Heart Valve Disease |
|
|
| Multiple Cranial Nerve Palsy |
|
|
| Cardiac Sarcoidosis |
|
|
| Potter'S Syndrome |
|
|
| Parotid Disease |
|
|
| Vasculogenic Impotence |
|
|
| Coronary Restenosis |
|
|
| Inherited Metabolic Disorder |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Rheumatic Heart Disease |
|
|
| Urinary Tract Infection |
|
|
| Myocardial Infarction |
|
|
| Pericardial Effusion |
|
|
| Diabetic Neuropathy |
|
|
| Facial Paralysis |
|
|
| Gingival Overgrowth |
|
|
| Aortic Valve Disease 1 |
|
|
| Silicosis |
|
|
| Pheochromocytoma |
|
|
| Peripheral Nervous System Disease |
|
|
| Hypertensive Retinopathy |
|
|
| Atrioventricular Block |
|
|
| Brawny Scleritis |
|
|
| Cystic Fibrosis |
|
|
| Hypertensive Encephalopathy |
|
|
| Ocular Tuberculosis |
|
|
| Lipid Metabolism Disorder |
|
|
| Chlorhexidine Allergy |
|
|
| Basilar Artery Occlusion |
|
|
| Mitral Valve Insufficiency |
|
|
| Patent Foramen Ovale |
|
|
| Anterolateral Myocardial Infarction |
|
|
| Tolosa-Hunt Syndrome |
|
|
| Melkersson-Rosenthal Syndrome |
|
|
| Angina Pectoris |
|
|
| Toxic Myocarditis |
|
|
| Anterior Scleritis |
|
|
| Cardiomyopathy, Familial Hypertrophic, 10 |
|
|
| Glucose Intolerance |
|
|
| Hypopyon |
|
|
| Tricuspid Valve Disease |
|
|
| Pneumonia |
|
|
| Inferior Myocardial Infarction |
|
|
| Acute Myocarditis |
|
|
| Prostatic Hypertrophy |
|
|
| Lymphangioleiomyomatosis |
|
|
| Acquired Metabolic Disease |
|
|
| Cranial Nerve Disease |
|
|
| Mediastinitis |
|
|
| Autosomal Recessive Alport Syndrome |
|
|
| Familial Hyperlipidemia |
|
|
| Arterial Calcification Of Infancy |
|
|
| Severe Nonproliferative Diabetic Retinopathy |
|
|
| Tetralogy Of Fallot |
|
|
| Restrictive Cardiomyopathy |
|
|
| Temporal Arteritis |
|
|
| Coronary Artery Vasospasm |
|
|
| Migraine With Aura |
|
|
| Cholesterol Embolism |
|
|
| Interstitial Nephritis |
|
|
| Membranoproliferative Glomerulonephritis |
|
|
| Facial Nerve Disease |
|
|
| Viral Exanthem |
|
|
| Coronavirus Infectious Disease |
|
|
| Pulmonary Sarcoidosis |
|
|
| Granulomatous Angiitis |
|
|
| Henoch-Schoenlein Purpura |
|
|
| Non-Severe Covid-19 |
|
|
| Alcoholic Cardiomyopathy |
|
|
| Cat-Scratch Disease |
|
|
| Viral Pneumonia |
|
|
| Schizophrenia |
|
|
| Substance Abuse |
|
|
| Diffuse Scleroderma |
|
|
| Uveal Disease |
|
|
| Muscle Hypertrophy |
|
|
| Inappropriate Adh Syndrome |
|
|
| Renal Tubular Dysgenesis |
|
|
| Coronary Aneurysm |
|
|
| Gaucher'S Disease |
|
|
| Infective Endocarditis |
|
|
| Renal Artery Atheroma |
|
|
| Asthma |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | ACE | MGD | MGI:87874 |
| Canis familiaris | ACE | VGNC | VGNC:97183 |
| Felis catus | ACE | VGNC | VGNC:97340 |
| Rattus norvegicus | ACE | RGD | RGD:2493 |
| Bos taurus | ACE | VGNC | VGNC:107264 |
| Others | ACE | NCBI |