SCAI - suppressor of cancer cell invasion Gene

Also Known as NET40; C9orf126

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 286205

About SCAI

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,942,608-125,143,528 (from NCBI)

This gene has 7 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in brain (RPKM 4.6), lung (RPKM 2.0) and 24 other tissues.

Summary

This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (Ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

SCAI Products (2)

mRNA Protein Name
NM_001144877.3 NP_001138349.1 protein SCAI isoform 2
NM_173690.5 NP_775961.2 protein SCAI isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
19350017 GOA
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
19350017 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
19350017 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCAI Protein Structure

SCAI

SCAI: Protein SCAI (63 - 558)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 606 a.a.
Protein Preferred Names Protein Names

protein SCAI

  • suppressor of cancer cell invasion protein

SCAI Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SCAI Q8N9R8 OGT Homo sapiens O15294-3
Y2H Prey Pooling
32296183
Intra
SCAI Q8N9R8 OGT Homo sapiens O15294-3
Y2H Array
32296183
Intra
SCAI Q8N9R8 CDIPT Homo sapiens O14735
Y2H Array
32296183
Intra
SCAI Q8N9R8 CDIPT Homo sapiens O14735
Y2H Prey Pooling
32296183
Intra
SCAI Q8N9R8 SOX7 Homo sapiens Q9BT81
Y2H Prey Pooling
32296183
Intra
SCAI Q8N9R8 SOX7 Homo sapiens Q9BT81
Validated Y2H
32296183
Intra
SCAI Q8N9R8 SOX7 Homo sapiens Q9BT81
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SCAI Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82161 SCAI Antibody (YA1906) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P82161A SCAI Antibody (YA1906)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Vertebral Artery Insufficiency

  • Vertebral Artery Syndrome
Lateral Myocardial Infarction
Spinocerebellar Ataxia, X-Linked 2

  • Scax2

  • X-Linked Spinocerebellar Ataxia 2

  • Cerebellar Ataxia With Extrapyramidal Involvement Early-Onset

  • Cerebellar Ataxia With Extrapyramidal Involvement, Early-Onset

  • Spinocerebellar Ataxia X-Linked Type 2
Subclavian Steal Syndrome

  • Subclavian Artery Stenosis

  • Subclavian Steal Phenomenon

  • Subclavian Steal Steno-Occlusive Disease

  • Subclavian Steal
Thrombophilia, X-Linked, Due To Factor Ix Defect

  • THPH8

  • Deep Venous Thrombosis, Protection Against

  • X-Linked Thrombophilia Due To Factor Ix Defect

  • Thrombophilia, X-Linked, Due To Factor 9 Defect

  • Thrombophilia 8, X-Linked, Due To Factor Ix Defect
Hyperinsulinemic Hypoglycemia, Familial, 4

  • Hyperinsulinism Due To Glutamodehydrogenase Deficiency

  • HHF4

  • Familial Hyperinsulinemic Hypoglycemia 4

  • Hyperinsulinemic Hypoglycemia Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency

  • Hyperinsulinism Due To Schad Deficiency

  • Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency

  • Congenital Hyperinsulinism

  • Schad Deficiency

  • Persistent Hyperinsulinemic Hypoglycemia Of Infancy

  • Phhi

  • 3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Left Bundle Branch Hemiblock

  • Left Bundle Branch Block

  • Left Bundle-Branch Block
Aortic Valve Insufficiency

  • Aortic Regurgitation

  • Rheumatic Aortic Regurgitation

  • Aortic Insufficiency

  • Rheumatic Aortic Insufficiency

  • Rheumatic Aortic Valve Insufficiency

  • Aortic Incompetence

  • Corrigan'S Disease

  • Rheumatic Aortic Valve Regurgitation

  • Aortic Valve Incompetency

  • Ai - [Aortic Incompetence]

  • Incompetent Aortic Valve

  • Ar - [Aortic Regurgitation]

  • Calcific Aortic Valve Regurgitation

  • Myxomatous Aortic Valve Regurgitation

  • Annular Incompetency Of Aortic Valve

  • Austin Flint Murmur

  • Flint Murmur

  • Rheumatic Aortic Incompetence

  • Rheumatic Ai - [Aortic Insufficiency]
Patent Foramen Ovale

  • Atrial Septal Defect Within Oval Fossa

  • Foramen Ovale Patent

  • Ostium Secundum Atrial Septal Defect

  • Atrial Septal Defect, Ostium Secundum Type

  • Foramen Ovale, Patent

  • Defect, Patent Or Persistent, Ostium Secundum

  • Ostium Secundum Type Atrial Septal Defect

  • Persistent Ostium Secundum

  • Asd Ostium Secundum Type

  • Ostium Secundum Asd

  • Osasd

  • Asd, Ostium Secundum Type

  • Pfo - [Patent Foramen Ovale]

  • Open Foramen Ovale

  • Open Oval Foramen

  • Persistent Foramen Ovale

  • Secundum Atrial Septal Defect
Lipoprotein Quantitative Trait Locus

  • Coronary Artery Disease

  • Coronary Artery Anomaly

  • Coronary Artery Disease, Susceptibility To

  • Myocardial Ischemia

  • Congenital Anomaly Of Coronary Artery

  • Coronary Arteriosclerosis

  • Coronary Disease

  • Coronary Heart Disease

  • Coronary Artery Disorder

  • LPAQTL

  • Lpa Deficiency, Congenital

  • Coronary Artery Abnormality

  • Coronary Artery Anomaly, Congenital

  • Chd

  • Coronary Syndrome

  • Congenital Malformations Of Coronary Vessels

  • Malformation Of Coronary Vessels

  • Congenital Coronary Artery Anomaly

  • Congenital Coronary Artery Deformity

  • Congenital Coronary Artery Disorder

  • Abnormal Coronary Artery

  • Congenital Coronary Artery Malposition

  • Congenital Coronary Disease

  • Congenital Anomaly Of Coronary Arteries
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12477 SCAI Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SCAI RGD RGD:1594720
Felis catus SCAI VGNC VGNC:102978
Mus musculus SCAI MGD MGI:2443716
Others SCAI NCBI