MLF1 - myeloid leukemia factor 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4291

About MLF1

Cytogenetic location: 3q25.32 Genomic coordinates (GRCh38): 3:158,571,194-158,606,456 (from NCBI)

This gene has 21 transcripts (splice variants), 192 orthologues, 1 paralogue and is associated with 55 phenotypes. Biased expression in testis (RPKM 97.9), heart (RPKM 24.2) and 4 other tissues.

Summary

This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

MLF1 Products (20)

mRNA Protein Name
NM_001130156.3 NP_001123628.1 myeloid leukemia factor 1 isoform 2
NM_001130157.3 NP_001123629.1 myeloid leukemia factor 1 isoform 2
NM_001195432.4 NP_001182361.2 myeloid leukemia factor 1 isoform 5
NM_001195433.2 NP_001182362.1 myeloid leukemia factor 1 isoform 4
NM_001195434.2 NP_001182363.1 myeloid leukemia factor 1 isoform 5
NM_001369781.1 NP_001356710.1 myeloid leukemia factor 1 isoform 7
NM_001369782.1 NP_001356711.1 myeloid leukemia factor 1 isoform 8
NM_001369783.1 NP_001356712.1 myeloid leukemia factor 1 isoform 6
NM_001369784.1 NP_001356713.1 myeloid leukemia factor 1 isoform 2
NM_001369785.1 NP_001356714.1 myeloid leukemia factor 1 isoform 5
NM_001378845.1 NP_001365774.1 myeloid leukemia factor 1 isoform 9
NM_001378846.1 NP_001365775.1 myeloid leukemia factor 1 isoform 5
NM_001378847.1 NP_001365776.1 myeloid leukemia factor 1 isoform 2
NM_001378848.1 NP_001365777.1 myeloid leukemia factor 1 isoform 2
NM_001378850.1 NP_001365779.1 myeloid leukemia factor 1 isoform 10
NM_001378851.1 NP_001365780.1 myeloid leukemia factor 1 isoform 11
NM_001378852.1 NP_001365781.1 myeloid leukemia factor 1 isoform 12
NM_001378853.1 NP_001365782.1 myeloid leukemia factor 1 isoform 13
NM_001378855.1 NP_001365784.1 myeloid leukemia factor 1 isoform 14
NM_022443.5 NP_071888.1 myeloid leukemia factor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
12176995 GOA
enables protein domain specific binding IDA
IDA: Inferred from direct assay
12176995 GOA
Biological Process GO Annotation Evidence Verweise Source
acts upstream of negative effect regulation of cell cycle G1/S phase transition IPI
IPI: Inferred from physical interaction
15861129 GOA
acts upstream of positive effect regulation of signal transduction by p53 class mediator IPI
IPI: Inferred from physical interaction
15861129 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15861129 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLF1 Protein Structure

Mlf1IP

Mlf1IP: Myelodysplasia-myeloid leukemia factor 1-interacting protein (26 - 203)

  • 0
  • 100
  • 200
  • 268 a.a.
Protein Preferred Names Protein Names

myeloid leukemia factor 1

  • myelodysplasia-myeloid leukemia factor 1

MLF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
MLF1 P58340 MLF2 Homo sapiens Q15773
Lumier
25036637
Intra
MLF1 P58340 DNAJB6 Homo sapiens O75190
Anti Tag CoIP
33961781
Intra
MLF1 P58340 BAG2 Homo sapiens O95816
Lumier
25036637
Intra
MLF1 P58340 BAG2 Homo sapiens O95816
Anti Tag CoIP
33961781
Intra
MLF1 P58340 YWHAE Homo sapiens P62258
ITC
22151054
Intra
MLF1 P58340 YWHAE Homo sapiens P62258
X-Ray Diffraction
22151054
Intra
MLF1 P58340 HAX1 Homo sapiens O00165
Lumier
25036637
Intra
MLF1 P58340 HAX1 Homo sapiens O00165
Anti Tag CoIP
33961781
Intra
MLF1 P58340 PSMD2 Homo sapiens Q13200
Lumier
25036637
Intra
MLF1 P58340 DNAJB2 Homo sapiens P25686
Anti Tag CoIP
33961781
Intra
MLF1 P58340 DNAJB2 Homo sapiens P25686
Lumier
25036637
Intra
MLF1 P58340 MAGEA11 Homo sapiens P43364
Validated Y2H
26871637
Intra
MLF1 P58340 MAGEA11 Homo sapiens P43364
Y2H Array
26871637
Intra
MLF1 P58340 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
26871637
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Thyroid Carcinoma

  • Thyroid Cancer

  • Malignant Neoplasm Of Thyroid

  • Thyroid Neoplasm
Myeloid Leukemia

  • Myeloid Leukaemia

  • Leukaemia Myelogenous

  • Leukemia Myelogenous

  • Myeloid Granulocytic Leukaemia

  • Myeloid Granulocytic Leukemia

  • Non-Lymphocytic Leukemia

  • Leukemia, Myeloid

  • Granulocytic Leukaemia

  • Myelogenous Leukaemia

  • Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Myelodysplastic Syndrome

  • Myelodysplastic Syndromes

  • Myelodysplasia

  • MDS

  • Myelodysplastic Syndrome Included

  • Myelodysplastic Syndrome, Susceptibility To, Included

  • Myelodysplastic Syndrome, Somatic

  • Myelodysplastic Syndrome, Susceptibility To
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Small Intestine Neuroendocrine Neoplasm

  • Small Intestine Neuroendocrine Tumor

  • Neuroendocrine Tumor Of The Small Intestine

  • Net Of The Small Intestine

  • Neuroendocrine Neoplasm Of The Small Intestine

  • Neuroendocrine Tumor Of Small Bowel

  • Small Intestinal Neuroendocrine Neoplasm
Unilateral Focal Polymicrogyria
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 1

  • Muscular Dystrophy, Limb-Girdle, Type 1e

  • Lgmd1d

  • Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1d

  • LGMDD1

  • Lgmd1e

  • Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1

  • Limb-Girdle Muscular Dystrophy Type 1d

  • Muscular Dystrophy, Limb-Girdle, Type 1d

  • Muscular Dystrophy, Limb-Girdle, Type 1d, Formerly

  • Lgmd1d, Formerly

  • Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1e

  • Muscular Dystrophy Limb-Girdle Type 1d

  • Muscular Dystrophy Limb-Girdle Type 1e

  • Dnajb6-Related Limb-Girdle Muscular Dystrophy D1

  • Dnajb6-Related Lgmd D1

  • Lgmd Type 1d

  • Limb-Girdle Muscular Dystrophy 1e

  • Limb-Girdle Muscular Dystrophy-1d, Autosomal Dominant

  • Dystrophy, Muscular, Limb-Girdle, Autosomal Dominant, Type 1

  • Dystrophy, Muscular, Limb-Girdle, Type 1e
Small Intestine Benign Neoplasm

  • Neoplasm Of Small Intestine

  • Small Intestinal Neoplasm

  • Neoplasm Of The Small Intestine

  • Small Bowel Cancer

  • Small Intestine Cancer

  • Malignant Neoplasm Of Small Intestine, Unspecified

  • Malignant Tumour Of Small Bowel

  • Malignant Tumour Of Small Intestine

  • Primary Malignant Neoplasm Of Meckel Diverticulum
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS08487 MLF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22237 Mlf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28759 Mlf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MLF1 RGD RGD:1306854
Mus musculus MLF1 MGD MGI:1341819