ANAPC11 - anaphase promoting complex subunit 11 Gene

Also Known as APC11; Apc11p; HSPC214

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51529

About ANAPC11

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,890,790-81,900,533 (from NCBI)

This gene has 23 transcripts (splice variants), 166 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.1), heart (RPKM 13.6) and 25 other tissues.

Summary

Enables cullin family protein binding activity and ubiquitin-ubiquitin Ligase activity. Contributes to ubiquitin-protein transferase activity. Involved in protein K11-linked ubiquitination. Located in nucleolus and nucleoplasm. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]

ANAPC11 Products (12)

mRNA Protein Name
NM_001002244.2 NP_001002244.1 anaphase-promoting complex subunit 11 isoform 1
NM_001002245.2 NP_001002245.1 anaphase-promoting complex subunit 11 isoform 2
NM_001002246.2 NP_001002246.1 anaphase-promoting complex subunit 11 isoform 2
NM_001002247.2 NP_001002247.1 anaphase-promoting complex subunit 11 isoform 2
NM_001002248.3 NP_001002248.1 anaphase-promoting complex subunit 11 isoform 2
NM_001002249.2 NP_001002249.1 anaphase-promoting complex subunit 11 isoform 2
NM_001289414.1 NP_001276343.1 anaphase-promoting complex subunit 11 isoform 2
NM_001289415.1 NP_001276344.1 anaphase-promoting complex subunit 11 isoform 2
NM_001289416.1 NP_001276345.1 anaphase-promoting complex subunit 11 isoform 2
NM_001289417.1 NP_001276346.1 anaphase-promoting complex subunit 11 isoform 2
NM_001289420.1 NP_001276349.1 anaphase-promoting complex subunit 11 isoform 4
NM_016476.11 NP_057560.8 anaphase-promoting complex subunit 11 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables cullin family protein binding IDA
IDA: Inferred from direct assay
10230407 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
10230407 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
11739784 GOA
enables ubiquitin-ubiquitin ligase activity IDA
IDA: Inferred from direct assay
10230407 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: Inferred from direct assay
29033132 GOA
involved in positive regulation of mitotic metaphase/anaphase transition IDA
IDA: Inferred from direct assay
11739784 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
18485873 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein branched polyubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
11739784 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of anaphase-promoting complex IDA
IDA: Inferred from direct assay
11739784 GOA
part of anaphase-promoting complex IPI
IPI: Inferred from physical interaction
27120157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANAPC11 Protein Structure

zf-ANAPC11

zf-ANAPC11: Anaphase-promoting complex subunit 11 RING-H2 finger (1 - 84)

  • 0
  • 84 a.a.
Protein Preferred Names Protein Names

anaphase-promoting complex subunit 11

  • APC11 anaphase promoting complex subunit 11 homolog

ANAPC11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ANAPC11 Q9NYG5 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra
ANAPC11 Q9NYG5 PEX1 Homo sapiens O43933
Y2H Array
32814053
Intra
ANAPC11 Q9NYG5 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Milker'S Nodule

  • Poxviridae Infections

  • Milker Nodule

  • Milkers' Node

  • Paravaccinia

  • Pseudocowpox

  • Milker'S Nodes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00679 ANAPC11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ANAPC11 VGNC VGNC:51919
Rattus norvegicus ANAPC11 RGD RGD:1561880
Bos taurus ANAPC11 VGNC VGNC:55771
Macaca mulatta ANAPC11 VGNC VGNC:99115
Mus musculus ANAPC11 MGD MGI:1913406
Others ANAPC11 NCBI