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PSMD10 - proteasome 26S subunit, non-ATPase 10 Gene

Also Known as p28; p28(GANK); dJ889N15.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5716

About PSMD10

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:108,084,207-108,091,542 (from NCBI)

This gene has 7 transcripts (splice variants), 225 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 23.6), thyroid (RPKM 20.0) and 25 other tissues.

Summary

This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S Proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]

PSMD10 Products (2)

mRNA	Protein	Name
NM_002814.4	NP_002805.1	26S proteasome non-ATPase regulatory subunit 10 isoform 1
NM_170750.3	NP_736606.1	26S proteasome non-ATPase regulatory subunit 10 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10613832	GOA
enables transcription factor binding	IPI IPI: Inferred from physical interaction	18040287	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cytoplasmic sequestering of NF-kappaB	IDA IDA: Inferred from direct assay	18040287	GOA
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	16023600	GOA
involved in negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	19729910	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	18040287	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	16023600	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19729910	GOA
involved in negative regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	19729910	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16023600	GOA
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	10613832	GOA
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11900540	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	16023600	GOA
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	16023600	GOA
involved in proteasome regulatory particle assembly	IMP IMP: Inferred from mutant phenotype	19490896	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18040287	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18040287	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA
part of proteasome regulatory particle, base subcomplex	IDA IDA: Inferred from direct assay	19490896	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD10 Protein Structure

Ank_2

Ank

Ank_2

0
100
200
226 a.a.

Protein Preferred Names	Protein Names
26S proteasome non-ATPase regulatory subunit 10	26S proteasome regulatory subunit p28

PSMD10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PSMD10	O75832	GRSF1	Homo sapiens	Q12849	Anti Bait CoIP	24338975
Intra	PSMD10	O75832	GRSF1	Homo sapiens	Q12849	Anti Tag CoIP	24338975
Intra	PSMD10	O75832	HSPA1A	Homo sapiens	P0DMV8	Pull Down	24338975
Intra	PSMD10	O75832	CLIC1	Homo sapiens	O00299	Pull Down	24338975
Intra	PSMD10	O75832	CLIC1	Homo sapiens	O00299	Anti Tag CoIP	24338975
Intra	PSMD10	O75832	CLIC1	Homo sapiens	O00299	Anti Bait CoIP	24338975
Intra	PSMD10	O75832	MAGEA4	Homo sapiens	P43358	Anti Bait CoIP	12525503
Intra	PSMD10	O75832	MAGEA4	Homo sapiens	P43358	Y2H	12525503
Intra	PSMD10	O75832	MAGEA4	Homo sapiens	P43358	Anti Tag CoIP	12525503
Intra	PSMD10	O75832	PSMC4	Homo sapiens	P43686	Anti Tag CoIP	19490896
Intra	PSMD10	O75832	PSMC4	Homo sapiens	P43686	Y2H	21988832
Intra	PSMD10	O75832	PSMC4	Homo sapiens	P43686	Anti Bait CoIP	17353931
Intra	PSMD10	O75832	PSMC4	Homo sapiens	P43686	Complementation	32296183
Intra	PSMD10	O75832	PSMC4	Homo sapiens	P43686	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PSMD10 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P70213	Gankyrin/PSMD10 Protein, Human	O75832-1 (M1-G226)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Uterine Corpus Sarcoma	Sarcoma Of Corpus Uteri Sarcoma Of Uterus Sarcoma Of The Corpus Uteri Uterine Sarcoma Sarcoma, Nos Of Uterus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS18873	Psmd10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11318	PSMD10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25364	Psmd10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PSMD10	VGNC	VGNC:97572
Canis familiaris	PSMD10	VGNC	VGNC:45106
Macaca mulatta	PSMD10	VGNC	VGNC:103851
Mus musculus	PSMD10	MGD	MGI:1858898
Rattus norvegicus	PSMD10	RGD	RGD:620350
Others	PSMD10	NCBI