KDM2B-IN-2
Based on 1 Customer Validation
KDM2B-IN-1 (Example 20) is an effective inhibitor of histone demethylase (KDM2B), with an IC50 value of 0.021 μM. KDM2B-IN-1 can be used in proliferative diseases, such as cancer research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.36%
- CAS. Nr.: 1965248-01-4
- Formel: C21H26N4O2S2
- Molecular Weight:430.59
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
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KDM2B 0.021 μM (IC50) |
In Vitro
KDM2b (histone demethylase) belongs to the JmjC domain family and is responsible for removing methyl marks from histones (such as H3K36me2). Its abnormality is closely related to cancer and other diseases of excessive proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1965248-01-4
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Appearance Solid
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Molecular Weight 430.59
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Formel C21H26N4O2S2
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Color Light brown to brown
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SMILES
O=S(C1=CC=C(C2=CSC=C2)C=C1)(N3C(N4CCN(C5CCC5)CC4)=NCC3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 31.25 mg/mL (72.57 mM; ultrasonic and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.3224 mL | 11.6120 mL | 23.2239 mL | 58.0599 mL |
| 5 mM | 0.4645 mL | 2.3224 mL | 4.6448 mL | 11.6120 mL | |
| 10 mM | 0.2322 mL | 1.1612 mL | 2.3224 mL | 5.8060 mL | |
| 15 mM | 0.1548 mL | 0.7741 mL | 1.5483 mL | 3.8707 mL | |
| 20 mM | 0.1161 mL | 0.5806 mL | 1.1612 mL | 2.9030 mL | |
| 25 mM | 0.0929 mL | 0.4645 mL | 0.9290 mL | 2.3224 mL | |
| 30 mM | 0.0774 mL | 0.3871 mL | 0.7741 mL | 1.9353 mL | |
| 40 mM | 0.0581 mL | 0.2903 mL | 0.5806 mL | 1.4515 mL | |
| 50 mM | 0.0464 mL | 0.2322 mL | 0.4645 mL | 1.1612 mL | |
| 60 mM | 0.0387 mL | 0.1935 mL | 0.3871 mL | 0.9677 mL |
KDM2B-IN-2 Related Classifications
HY-139561 Related Classifications
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