Kibdelone C
Kibdelone C is a hexacyclic tetrahydroxanthone natural product and anticancer agent with sub-nanomolar GI50 activity against human SR leukemia and SN12C renal carcinoma cell lines. Kibdelone C disrupts the actin cytoskeleton in human cancer cells, leading to cell contraction and actin stress fiber formation, without direct actin binding, actin polymerization effects, topoisomerase I/II inhibition, or DNA binding. Kibdelone C can be used for the research of leukemia, and renal cell carcinoma.
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- CAS. Nr.: 934464-79-6
- Formel: C29H28ClNO10
- Molecular Weight:585.99
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Kibdelone C (10-100 nM) does not directly interact with actin or affect its in vitro polymerization, even at concentrations up to 100 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 934464-79-6
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Appearance Solid
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Molecular Weight 585.99
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Formel C29H28ClNO10
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Color Light yellow to yellow
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SMILES
OC1=C2C3=C(O)C(C(N(C(CCC)=C4Cl)C)=O)=C4C(O)=C3CCC2=C(C5=C1C(C6=C([C@H](C[C@@H]([C@@H]6O)O)O)O5)=O)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Sloman DL, et al. Total synthesis and absolute stereochemical assignment of kibdelone C. J Am Chem Soc. 2011;133(26):9952-9955. [Content Brief]
[2]. Rujirawanich J, et al. Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives. J Am Chem Soc. 2016;138(33):10561-10570. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Kibdelone C Related Classifications
HY-121352 Related Classifications
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- Kibdelone C
- 934464-79-6
- Drug Derivative
- human SR leukemia cell lines
- SN12C renal carcinoma cell lines
- HCT116 human colon cancer cells
- H2122 human non-small cell lung cancer cells
- HeLa human cervical cancer cells
- renal cell carcinoma
- leukemia
- H157 human non-small cell lung cancer cells
- H2073 human non-small cell lung cancer cells
- actin cytoskeleton
- Inhibitor
- inhibitor
- inhibit