LysoPC(18:3)
LysoPC (18:3) is a type of lysophospholipid metabolite with biomarker properties. LysoPC (18:3) stably exists in human follicular fluid, and its abundance dynamically changes with age, synchronously regulating the body's lipid metabolism process, follicular development process and oocyte maturation process. The down-regulation of LysoPC (18:3) content is associated with breast cancer lesions and follicular aging changes accompanied by in vitro fertilization in elderly women. LysoPC (18:3) can be used in studies related to breast cancer and infertility in elderly women.
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- CAS. Nr.: 62512-91-8
- Formel: C26H48NO7P
- Molecular Weight:517.64
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Speicherung:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Human Endogenous Metabolite |
LysoPC (18:3) abundance in human peripheral blood can serve as one of the lipid biomarkers to indicate the presence of breast cancer in vivo[2].
LysoPC (18:3) level inside human ovarian follicular microenvironment positively correlates with maternal age and negatively correlates with oocyte developmental potential in IVF patients[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 62512-91-8
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Appearance Oil
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Molecular Weight 517.64
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Formel C26H48NO7P
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Color Light yellow to yellow
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SMILES
CC/C=C\C/C=C\C/C=C\CCCCCCCC(OC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
Ethanol : 100 mg/mL (193.18 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.83 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.83 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.83 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.9318 mL | 9.6592 mL | 19.3184 mL | 48.2961 mL |
| 5 mM | 0.3864 mL | 1.9318 mL | 3.8637 mL | 9.6592 mL | |
| 10 mM | 0.1932 mL | 0.9659 mL | 1.9318 mL | 4.8296 mL | |
| 15 mM | 0.1288 mL | 0.6439 mL | 1.2879 mL | 3.2197 mL | |
| 20 mM | 0.0966 mL | 0.4830 mL | 0.9659 mL | 2.4148 mL | |
| 25 mM | 0.0773 mL | 0.3864 mL | 0.7727 mL | 1.9318 mL | |
| 30 mM | 0.0644 mL | 0.3220 mL | 0.6439 mL | 1.6099 mL | |
| 40 mM | 0.0483 mL | 0.2415 mL | 0.4830 mL | 1.2074 mL | |
| 50 mM | 0.0386 mL | 0.1932 mL | 0.3864 mL | 0.9659 mL | |
| 60 mM | 0.0322 mL | 0.1610 mL | 0.3220 mL | 0.8049 mL | |
| 80 mM | 0.0241 mL | 0.1207 mL | 0.2415 mL | 0.6037 mL | |
| 100 mM | 0.0193 mL | 0.0966 mL | 0.1932 mL | 0.4830 mL |
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