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Art. -Nr.: HY-187523

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Methylolanthanin

Name: Methylolanthanin
Brand: MedChemExpress
SKU: HY-187523
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(Synonyms: para-MLL)

Methylolanthanin (para-MLL) is a natural small-molecule metallophore identified in the culture supernatant of Methylobacterium extorquens AM1. Methylolanthanin binds lanthanide metal ions such as La³⁺, Nd³⁺ and Lu³⁺. It is applicable to studies related to lanthanide metabolism, bacterial metallophores, metal homeostasis and methylotrophic metabolism.

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CAS. Nr.: 3120945-90-3
Formel: C₄₀H₅₈N₆O₁₁
Molecular Weight:798.92

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Methylolanthanin Chemical Structure

CAS. Nr.: 3120945-90-3

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Biologische Aktivität
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- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Biologische Aktivität

Beschreibung

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Methylolanthanin (para-MLL) (10 μM; 15 min) forms insoluble complexes with La³⁺, Nd³⁺, Eu³⁺, and Lu³⁺ at pH 6.0, causing the complexes to precipitate from the solution^[1].
Methylolanthanin (18.75 μM) exhibits low iron (III)-binding affinity and only weak ability to compete with the CAS/HDTMA complex for Fe³⁺ at pH 6.0^[1].
Methylolanthanin forms the [MLL-H+Ln³⁺]²⁺ complex with La³⁺, Nd³⁺ and Lu³⁺^[2].
Methylolanthanin (50 nM) significantly increases the growth yield of M. extorquens AM1 ΔmxaF and ΔmxaFΔmll mutants under conditions of 2 μM or 50 nM NdCl₃^[2].
Methylolanthanin binds Eu³⁺ within the micromolar and nanomolar concentration ranges and forms detectable Eu³⁺-MLL particles, with a log K_SP of -12.07 for the precipitated complex^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS. Nr. 3120945-90-3
Molecular Weight 798.92
Formel C₄₀H₅₈N₆O₁₁
SMILES

O=C(C(CC(NCCCCN(CCCCNC(C1=CC=C(C=C1)O)=O)C(C)=O)=O)(CC(NCCCCN(CCCCNC(C2=CC=C(C=C2)O)=O)C(C)=O)=O)O)O
Synonyms

para-MLL
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Mertens MW, et al. Synthesis of two methylolanthanin derivatives and the investigation of their lanthanide and iron binding capabilities. Dalton transactions (Cambridge, England : 2003). 2026 Jul 14. [Content Brief]

[2]. Zytnick AM, et al. Identification and characterization of a small-molecule metallophore involved in lanthanide metabolism. Proc Natl Acad Sci U S A. 2024;121(32):e2322096121.

[3]. Gutenthaler-Tietze SM, et al. Comparative Binding Studies of the Chelators Methylolanthanin and Rhodopetrobactin B to Lanthanides and Ferric Iron. ChemBioChem. 2026;27(1):e202500312.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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