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ONC-841

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ONC-841 is a blood-brain barrier-permeable, humanized monoclonal antibody targeting SIGLEC10. As an immune checkpoint inhibitor, ONC-841 restores the functions of immune effector cells such as T cells and enhances anti-tumor immune responses by blocking inhibitory signals mediated by SIGLEC10. ONC-841 restores the phagocytic and migratory activities of microglia, and promotes the phagocytosis of Amyloid-β and Tau protein aggregates by microglia. ONC-841 is applicable to research related to solid tumors and Alzheimer's disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit: 95.03%
  • Molecular Weight:145.08 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for ONC-841
  • Experimental Validation Results for ONC-841
  • ONC-841 Chemical Structure
    ONC-841 Chemical Structure
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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ONC-841 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Immobilized Siglec-10-hFc can bind ONC-841. The EC50 for this effect is 34.77 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells labeling Siglec-10 with ONC-841 (HY-P991480, red). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • ONC-841 Chemical Structure
    1/16
  • ONC-841
  • Immobilized Siglec-10-hFc can bind ONC-841. The EC50 for this effect is 34.77 ng/mL.
  • Flow cytometric analysis of 1X106 Jurkat cells labeling Siglec-10 with ONC-841 (HY-P991480, red). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).