Resolvin D1
Based on 1 publication(s) in Google Scholar
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages.
The product specifications provided below refer solely to the active content of Resolvin D1.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.6%
- CAS. Nr.: 872993-05-0
- Formel: C22H32O5
- Molecular Weight:376.49
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Speicherung:
Solution, -20°C, 2 years
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Publications Citing Use of MedChemExpress (MCE) Resolvin D1
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Biologische Aktivität
Beschreibung
The product specifications provided below refer solely to the active content of Resolvin D1.
IC50 & Target
[1]|
Human Endogenous Metabolite |
In Vitro
Resolvin D1 (RvD1) (1-100 nM; 15 minutes) induces dose-dependent short-term functional changes in primary human macrophages. RvD1 triggers intracellular Ca2+ release, blocks chemotactic migration, and stimulates phagocytosis of microbial particles with maximal efficiency at 10 nM[1]. Resolvin D1 (0-500 nM; 72 hours) shows a strong inhibition of LPS-induced TRAP and cathepsin K expression by RvD1 at different concentrations in RAW264.7 macrophages[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:18-20 g thirty 8-week-old female DBA/1J mice (collagen antibody-induced arthritis (CAIA))[3]
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Dosage:100, 500, and 1000 ng (or 1000 ng, daily on days 4-10)
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Administration:i.p. injection; daily on days 10
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Result:Exhibit a reduced arthritic score.
- Phagocytosis Functional Assay
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Annexin V plus membrane-impermeant dye apoptosis staining
- Cell migration
- Carrageenan-Induced Paw Edema
- Zymosan-Induced Peritonitis
- Apoptosis Solutions
- Research Protocol for Inflammation-related Diseases
- Phalloidin F-actin cytoskeleton staining
Chemical Information
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CAS. Nr. 872993-05-0
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Appearance Liquid
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Molecular Weight 376.49
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Formel C22H32O5
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Color Colorless to light yellow
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SMILES
CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(O)=O)O)O)O
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Synonyms
RvD1
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, 2 years
Publications (1)
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Journal Impact Factor
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Most Recent
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Schmid M, et al. Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32. J Immunol. 2016 Apr 15;196(8):3429-37. [Content Brief]
[2]. Gao Y, et al. Resolvin D1 Improves the Resolution of Inflammation via Activating NF-κB p50/p50-Mediated Cyclooxygenase-2 Expression in Acute Respiratory Distress Syndrome. J Immunol. 2017 Aug 9. pii: ji1700315. [Content Brief]
[3]. Benabdoun HA, et al. In vitro and in vivo assessment of the proresolutive and antiresorptive actions of resolvin D1: relevance to arthritis. Arthritis Res Ther. 2019 Mar 12;21(1):72. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Resolvin D1 Related Classifications
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