Thalidomide-O-PEG4-NHS ester
Based on 1 Customer Validation
Thalidomide-O-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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- Reinheit : 98.76%
- CAS. Nr.: 2411681-88-2
- Formel: C28H33N3O13
- Molecular Weight:619.57
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Alle E3 Ligase Ligand-Linker Conjugates Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS. Nr. 2411681-88-2
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Appearance Solid-Liquid Mixture
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Molecular Weight 619.57
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Formel C28H33N3O13
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Color Light yellow to light brown
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SMILES
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 25 mg/mL (40.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6140 mL | 8.0701 mL | 16.1402 mL | 40.3506 mL |
| 5 mM | 0.3228 mL | 1.6140 mL | 3.2280 mL | 8.0701 mL | |
| 10 mM | 0.1614 mL | 0.8070 mL | 1.6140 mL | 4.0351 mL | |
| 15 mM | 0.1076 mL | 0.5380 mL | 1.0760 mL | 2.6900 mL | |
| 20 mM | 0.0807 mL | 0.4035 mL | 0.8070 mL | 2.0175 mL | |
| 25 mM | 0.0646 mL | 0.3228 mL | 0.6456 mL | 1.6140 mL | |
| 30 mM | 0.0538 mL | 0.2690 mL | 0.5380 mL | 1.3450 mL | |
| 40 mM | 0.0404 mL | 0.2018 mL | 0.4035 mL | 1.0088 mL |
Thalidomide-O-PEG4-NHS ester Related Classifications
HY-141012 Related Classifications
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