TLR4 agonist-2
TLR4 agonist-2 is a TLR4 agonist with EC50 values of 0.82 μM and 0.43 μM for mTLR4 and hTLR4, respectively. TLR4 agonist-2 induces the production of TLR4-dependent cytokines and chemokines. TLR4 agonist-2 can be used for immunological research.
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- CAS. Nr.: 2148927-98-2
- Formel: C31H30N4O2S
- Molecular Weight:522.66
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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hTLR4 0.82 μM (EC50) |
mTLR4 0.43 μM (EC50) |
TLR4 agonist-2 (Compound 36) (5 μM; overnight) potently induces the release of IL-6 and CCL5 from primary mouse bone marrow-derived dendritic cells[1].
TLR4 agonist-2 potently induces the release of IL8 and IL-6 from primary human peripheral blood mononuclear cells[1].
TLR4 agonist-2 (5 μM; overnight) shows no significant toxicity to human hepatocellular carcinoma cells HepG2 at the concentration of 5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 human hepatocellular carcinoma cells
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Concentration:5 μM
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Incubation Time:overnight
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Result:Showed no significant difference in cell viability compared to reference compound 1, vehicle control (DMSO), and positive controls (1Y136, LPS).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6[1]
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Dosage:20 nmol
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Administration:i.v.; single dose
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Result:Induced significantly higher serum levels of the chemokine KC (keratinocyte chemoattractant; CXCL1) and IP-10 at 3 hours post-injection.
Showed a trend toward higher serum IL-6 levels at 3 hours post-injection.
Chemical Information
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CAS. Nr. 2148927-98-2
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Molecular Weight 522.66
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Formel C31H30N4O2S
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SMILES
CN1C2=CC=C(C=C2C3=C1C(N(C(SCC(NC4CCCCC4)=O)=N3)C5=CC=CC=C5)=O)C6=CC=CC=C6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TLR4 agonist-2 Related Classifications
HY-186271 Related Classifications
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- TLR4 agonist-2
- 2148927-98-2
- Toll-like Receptor (TLR)
- human TLR4
- murine TLR4 reporter cells
- HepG2 human hepatocellular carcinoma cells
- LPS binding pocket
- TLR4/MD-2 complex
- primary murine bone marrow-derived dendritic cells
- C57BL/6 mice
- primary human peripheral blood mononuclear cells
- human TLR4 reporter cells
- TLR4 signaling
- Inhibitor
- inhibitor
- inhibit