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Cat. No.: HY-W1130429

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4A3-SC10

4A3-SC10 is an ionizable cationic lipid (pK_a = 6.57) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. 4A3-SC10 can be used for drug delivery in cancer.

For research use only. We do not sell to patients.

CAS No.: 1857340-80-7
Formula: C₈₃H₁₅₅N₃O₁₆S₄
Molecular Weight:1579.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

4A3-SC10 Chemical Structure

CAS No.: 1857340-80-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 1857340-80-7
Molecular Weight 1579.39
Formula C₈₃H₁₅₅N₃O₁₆S₄
SMILES

CCCCCCCCCCSCC(C(OCCOC(CCN(CCCN(CCCN(CCC(OCCOC(C(CSCCCCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCCCCC)C)=O)=O)C)CCC(OCCOC(C(CSCCCCCCCCCC)C)=O)=O)=O)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen Z, et al. Modular Design of Biodegradable Ionizable Lipids for Improved mRNA Delivery and Precise Cancer Metastasis Delineation In Vivo. J Am Chem Soc. 2023 Nov 8;145(44):24302-24314. [Content Brief]

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Topics Lipid Nanoparticles: Key Nucleic Acid Delivery Vectors
Lipid nanoparticles (LNPs) are the most clinically advanced non-viral delivery systems for nucleic acid therapeutics and enable the in vivo delivery of mRNA, siRNA, and other genetic cargos.

2026-06-18

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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