Alpha-Estradiol-d2
Based on 1 Customer Validation
Alpha-Estradiol-d2 is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 81586-94-9
- Formula: C18H22D2O2
- Molecular Weight:274.39
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 81586-94-9
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Unlabeled Cas 57-91-0
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Appearance Solid
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Molecular Weight 274.39
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Formula C18H22D2O2
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Color White to off-white
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SMILES
C[C@@]12[C@H](O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=C([2H])C(O)=C4[2H])[C@@]3([H])CC2
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Synonyms
Alfatradiol-d2; Epiestradiol-d2; Epiestrol-d2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 62.5 mg/mL (227.78 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 11.11 mg/mL (40.49 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Schriefers H, et al. Inhibition of testosterone metabolism by 17-alpha-estradiol in rat liver slices. Arzneimittelforschung. 1991 Nov;41(11):1186-9. [Content Brief]
[4]. Zhang HB, et al. 17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model. Jpn J Ophthalmol. 2012 Jul;56(4):407-15. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 3.6444 mL | 18.2222 mL | 36.4445 mL | 91.1112 mL |
| 5 mM | 0.7289 mL | 3.6444 mL | 7.2889 mL | 18.2222 mL | |
| 10 mM | 0.3644 mL | 1.8222 mL | 3.6444 mL | 9.1111 mL | |
| 15 mM | 0.2430 mL | 1.2148 mL | 2.4296 mL | 6.0741 mL | |
| 20 mM | 0.1822 mL | 0.9111 mL | 1.8222 mL | 4.5556 mL | |
| 25 mM | 0.1458 mL | 0.7289 mL | 1.4578 mL | 3.6444 mL | |
| 30 mM | 0.1215 mL | 0.6074 mL | 1.2148 mL | 3.0370 mL | |
| 40 mM | 0.0911 mL | 0.4556 mL | 0.9111 mL | 2.2778 mL | |
| DMSO | 50 mM | 0.0729 mL | 0.3644 mL | 0.7289 mL | 1.8222 mL |
| 60 mM | 0.0607 mL | 0.3037 mL | 0.6074 mL | 1.5185 mL | |
| 80 mM | 0.0456 mL | 0.2278 mL | 0.4556 mL | 1.1389 mL | |
| 100 mM | 0.0364 mL | 0.1822 mL | 0.3644 mL | 0.9111 mL |
Alpha-Estradiol-d2 Related Classifications
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