2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. Avotaciclib sulfate

Avotaciclib (BEY1107) sulfate is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib sulfate can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib sulfate can be used in the research of cancer such as pancreatic cancer and lung cancer.

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Avotaciclib sulfate

Avotaciclib sulfate Estructura química

No. CAS : 1983984-04-8

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Avotaciclib sulfate Related Antibodies

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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Descripciòn

Avotaciclib (BEY1107) sulfate is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib sulfate can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib sulfate can be used in the research of cancer such as pancreatic cancer and lung cancer[1][2].

IC50 & Target[1]

CDK1

 

In Vitro

Avotaciclib (0-64 μM; 48 h) sulfate can inhibit cell proliferation and promote apoptosis in radiotherapy-resistant non-small cell lung cancer cell lines, and the effect is better when combined with PV-1019 (HY-125203)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Avotaciclib sulfate Related Antibodies

Cell Viability Assay[2]

Cell Line: Non-small cell lung cancer cells (H1437R, H1568R, H1703R and H1869R)
Concentration: 0, 0.1, 1, 2, 4, 8, 16, 32 and 64 μM
Incubation Time: 48 h
Result: Inhibited the cell viability, with EC50 values of 0.918, 0.580, 0.735 and 0.662 μM for H1437R, H1568R, H1703R and H1869R, respectively.
Peso molecular

379.35

Fòrmula

C13H13N7O5S
No. CAS
SMILES

OC1=CC=C(C2=NC(N)=NC=C2)N=C1C3=NC(N)=NC=C3.O=S(O)(O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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Avotaciclib sulfate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avotaciclib1983984-04-8BEY1107BEY 1107BEY-1107CDKApoptosisCyclin dependent kinaseorallyactivecyclindependentkinasecancerNon-small cell lung cancer cells (H1437RH1568RH1703R and H1869R)Inhibitorinhibitorinhibit

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Nombre del producto:
Avotaciclib sulfate
Cat. No.:
HY-137432D
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