BCRP-IN-1
BCRP-IN-1 (compound 48) is a potent inhibitor of breast cancer resistance protein (BCRP), with IC50s of 2.92 μM and 2.46 μM in Hoechst 33342 assay and Pheophorbide A assay, respectively.
For research use only. We do not sell to patients.
- CAS No.: 765899-28-3
- Formula: C16H14N4O4
- Molecular Weight:326.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MDCK-II | IC50 |
2.46 μM
Compound: 48
|
Inhibition of human BCRP expressed in MDCK2 cells assessed as pheophorbide A accumulation treated 30 mins before pheophorbide A addition measured up to 120 mins by flow cytometry
Inhibition of human BCRP expressed in MDCK2 cells assessed as pheophorbide A accumulation treated 30 mins before pheophorbide A addition measured up to 120 mins by flow cytometry
|
[PMID: 24184213] |
| MDCK-II | IC50 |
2.92 μM
Compound: 48
|
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation treated 30 mins before Hoechst 33342 addition measured up to 120 mins by fluorescence assay
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation treated 30 mins before Hoechst 33342 addition measured up to 120 mins by fluorescence assay
|
[PMID: 24184213] |
Chemical Information
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CAS No. 765899-28-3
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Molecular Weight 326.31
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Formula C16H14N4O4
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SMILES
O=[N+](C1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1)[O-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)