2. Anti-infection
  3. HIV
  4. BMS-585248

BMS-585248 is a potent, third-generation HIV-1 attachment inhibitor with a promising initial in vitro and in vivo pharmacokinetic profile.

For research use only. We do not sell to patients.

BMS-585248 Chemical Structure

BMS-585248 Chemical Structure

CAS No. : 619331-12-3

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BMS-585248 Related Antibodies

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Description

BMS-585248 is a potent, third-generation HIV-1 attachment inhibitor with a promising initial in vitro and in vivo pharmacokinetic profile[1].

IC50 & Target

HIV-1

 

In Vivo

BMS-585248 (intravenous (1 mg/kg) and oral (5-200 mg/kg); once) has a good pharmacokinetic profile, with AUC values of 3220 nM·h and 8064 nM·h after IV (1 mg/kg) and oral (5 mg/kg) administration in male rats, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats[1]
Dosage: 5, 15, and 200 mg/kg
Administration: Orally, once (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of BMS-585248 in male rats[1].
PO
Dose (mg/kg) 15 75 200
Cmax (μM) 6.6 8.4 11
AUCtot (μM·h) 42 115 145
Molecular Weight

447.42

Formula

C22H18FN7O3
CAS No.
SMILES

O=C(N1CCN(C(C2=CC=CC=C2)=O)CC1)C(C3=CNC4=C3C(F)=CN=C4N5N=NC=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMS-585248 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-585248619331-12-3BMS585248BMS 585248HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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HY-13829
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