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Cat. No.: HY-103041

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TP-061

TP-061 (Compound 30) is a Brr2 inhibitor with an IC₅₀ of 42 nM for Brr2 ATPase.

For research use only. We do not sell to patients.

CAS No.: 2133440-09-0
Formula: C₂₁H₂₅FN₄O₂
Molecular Weight:384.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

TP-061 Chemical Structure

CAS No.: 2133440-09-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

TP-061 (Compound 30) is a Brr2 inhibitor with an IC₅₀ of 42 nM for Brr2 ATPase^[1].

All DNA/RNA Synthesis Isoforms :

Chemical Information

CAS No. 2133440-09-0
Molecular Weight 384.45
Formula C₂₁H₂₅FN₄O₂
SMILES

O=C1NC2=C(C=C(F)C=C2)[C@]13N(C(C4=CN(C)C=N4)=O)[C@@H](CC(C)C)C[C@H]3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ito M, et al. Discovery of spiro[indole-3,2'-pyrrolidin]-2(1H)-one based inhibitors targeting Brr2, a core component of the U5 snRNP. Bioorg Med Chem. 2017 Sep 1;25(17):4753-4767. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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TP-061

All DNA/RNA Synthesis Isoforms