c-Met-IN-23
c-Met-IN-23 (Compound 12g) is a c-Met inhibitor (IC50 = 0.052 μM for c-Met). c-Met-IN-23 also inhibits MDR1 and MRP1/2 pumps in the cancerous HepG2 and BxPC3 cells. c-Met-IN-23 is an anticancer agent.
For research use only. We do not sell to patients.
- CAS No.: 3032969-28-8
- Formula: C16H13N7O
- Molecular Weight:319.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
c-Met-IN-23 (72 h) inhibits HGF-induced cell proliferation, with IC50s of 12.4, 3.06, 19.30, 16.85 µM for HT29, HepG2, MCF7, MDA-MB-231 cells respectively[1].
c-Met-IN-23 (0.3-150 µM, 30 min) blocks P-gp and MRP1/2 pumps in both HepG2 and BxPC3 cells[1].
c-Met-IN-23 (3 µM, 24 h) increases the expression of P-gp in HepG2 and BxPC3 cells, as well as MRP1 and MRP2 in BxPC3 cells, and inhibits the P-gp-mediated efflux in HepG2 cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3032969-28-8
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Molecular Weight 319.32
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Formula C16H13N7O
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SMILES
OC1=CC=C(C2=NN3C(N=C2)=NN=C3NCC4=CC=NC=C4)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
c-Met-IN-23 Related Classifications
HY-161353 Related Classifications
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