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Cat. No.: HY-161353

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c-Met-IN-23

c-Met-IN-23 (Compound 12g) is a c-Met inhibitor (IC₅₀ = 0.052 μM for c-Met). c-Met-IN-23 also inhibits MDR1 and MRP1/2 pumps in the cancerous HepG2 and BxPC3 cells. c-Met-IN-23 is an anticancer agent.

For research use only. We do not sell to patients.

CAS No.: 3032969-28-8
Formula: C₁₆H₁₃N₇O
Molecular Weight:319.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

c-Met-IN-23 Chemical Structure

CAS No.: 3032969-28-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

c-Met-IN-23 (72 h) inhibits HGF-induced cell proliferation, with IC₅₀s of 12.4, 3.06, 19.30, 16.85 µM for HT29, HepG2, MCF7, MDA-MB-231 cells respectively^[1].
c-Met-IN-23 (0.3-150 µM, 30 min) blocks P-gp and MRP1/2 pumps in both HepG2 and BxPC3 cells^[1].
c-Met-IN-23 (3 µM, 24 h) increases the expression of P-gp in HepG2 and BxPC3 cells, as well as MRP1 and MRP2 in BxPC3 cells, and inhibits the P-gp-mediated efflux in HepG2 cell^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 3032969-28-8
Molecular Weight 319.32
Formula C₁₆H₁₃N₇O
SMILES

OC1=CC=C(C2=NN3C(N=C2)=NN=C3NCC4=CC=NC=C4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Khatir ZZ, et al. 4-{3-[(Pyridin-4-ylmethyl)amino]-[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl}phenol: An improved anticancer agent in hepatocellular carcinoma and a selective MDR1/MRP modulator. Arch Pharm (Weinheim). 2024 Mar 5:e2300704. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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