DPP3 - dipeptidyl peptidase 3 Gene

Also Known as DPPIII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10072

About DPP3

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,480,434-66,509,657 (from NCBI)

This gene has 16 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in colon (RPKM 13.2), appendix (RPKM 10.5) and 25 other tissues.

Summary

This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl Aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]

DPP3 Products (3)

mRNA Protein Name
NM_001256670.2 NP_001243599.1 dipeptidyl peptidase 3 isoform 2
NM_005700.5 NP_005691.2 dipeptidyl peptidase 3 isoform 1
NM_130443.4 NP_569710.2 dipeptidyl peptidase 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables dipeptidyl-peptidase activity IDA
IDA: Inferred from direct assay
9425109 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
9425109 GOA
Biological Process GO Annotation Evidence References Source
involved in proteolysis IDA
IDA: Inferred from direct assay
9425109 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPP3 Protein Structure

Peptidase_M49

Peptidase_M49: Peptidase family M49 (143 - 704)

  • 0
  • 200
  • 400
  • 600
  • 737 a.a.
Protein Preferred Names Protein Names

dipeptidyl peptidase 3

  • DPP III

DPP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DPP3 Q9NY33 KEAP1 Homo sapiens Q14145
Y2H Prey Pooling
32296183
Intra
DPP3 Q9NY33 KEAP1 Homo sapiens Q14145
Y2H Array
25416956
Intra
DPP3 Q9NY33 KEAP1 Homo sapiens Q14145
Y2H Array
32296183
Intra
DPP3 Q9NY33 KEAP1 Homo sapiens Q14145
Validated Y2H
25416956
Intra
DPP3 Q9NY33 KEAP1 Homo sapiens Q14145
Anti Tag CoIP
33961781
Intra
DPP3 Q9NY33 KEAP1 Homo sapiens Q14145
Y2H
21516116
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DPP3 Proteins

Cat. No. Product Name Accession Purity
HY-P70112 Dipeptidyl peptidase 3/DPP3 Protein, Human (His) Q9NY33 (M1-A737) ≥ 90%, as determined by reducing SDS-PAGE.

DPP3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86848 DPP3 Antibody (YA6541) WB, IHC-P, FC Human

Related Diseases

Diseases Alias
Cardiac Arrest

  • Cardiopulmonary Arrest

  • Circulatory Arrest

  • Heart Arrest
Myasthenic Syndrome, Congenital, 10

  • Congenital Myasthenic Syndrome 10

  • CMS10

  • Lgm

  • Myasthenia, Limb-Girdle, Familial

  • Myasthenia, Limb-Girdle, Familial, Formerly

  • Lgm, Formerly

  • Congenital Myasthenic Syndrome Type Ib, Formerly

  • Cms1b, Formerly

  • Cms Ib, Formerly

  • Myasthenic Myopathy, Formerly

  • Familial Limb-Girdle Myasthenia

  • Cms1b

  • Cms Ib

  • Congenital Myasthenic Syndrome Type 1b

  • Congenital Myasthenic Syndrome Type Ib

  • Myasthenic Myopathy

  • Myasthenic Syndrome, Congenital, Type 10

  • Congenital Myasthenic Syndrome Ib

  • Myopathy In Myasthenia Gravis
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991050 Procizumab Inhibitor 99% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W074143 Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride 99.78% Unkown
HY-W127832 Ru(dpp)3(PF6)2 98.20% Unkown
HY-RS03962 DPP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-135534 Lysine 4-nitroanilide / Unkown
HY-N15181 Fluostatin B Inhibitor / Unkown
HY-RS18349 Dpp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24828 Dpp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991692 Invobenitug Inhibitor 99.10% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DPP3 VGNC VGNC:61603
Rattus norvegicus DPP3 RGD RGD:621127
Mus musculus DPP3 MGD MGI:1922471
Canis familiaris DPP3 VGNC VGNC:40073
Bos taurus DPP3 VGNC VGNC:28187
Others DPP3 NCBI