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CTSO - cathepsin O Gene

Also Known as CTSO1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1519

About CTSO

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,924,118-155,953,866 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 213 orthologues and 12 paralogues. Ubiquitous expression in gall bladder (RPKM 28.4), liver (RPKM 26.2) and 25 other tissues.

Summary

The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This Proteolytic Enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]

CTSO Products (1)

mRNA	Protein	Name
NM_001334.3	NP_001325.1	cathepsin O preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTSO Protein Structure

Peptidase_C1

0
100
200
300
321 a.a.

Protein Preferred Names	Protein Names
cathepsin O

CTSO Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CTSO	P43234	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32814053
Intra	CTSO	P43234	LMO3	Homo sapiens	Q8TAP4-4	Y2H Array	32814053
Intra	CTSO	P43234	LMO3	Homo sapiens	Q8TAP4-4	Y2H Pooling	32814053
Intra	CTSO	P43234	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	CTSO	P43234	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	CTSO	P43234	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	CTSO	P43234	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	CTSO	P43234	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	CTSO	P43234	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	CTSO	P43234	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	CTSO	P43234	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	CTSO	P43234	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	CTSO	P43234	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	CTSO	P43234	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	CTSO	P43234	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Orofaciodigital Syndrome V	OFD5 Thurston Syndrome Orofaciodigital Syndrome 5 Polydactyly, Postaxial, With Median Cleft Of Upper Lip Ofds V Oral-Facial-Digital Syndrome, Type V Orofaciodigital Syndrome, Thurston Type Orofaciodigital Syndrome Thurston Type Oral-Facial-Digital Syndrome 5 Polydactyly Postaxial With Median Cleft Of Upper Lip Ofd Syndrome 5 Ofds 5 Oral Facial Digital Syndrome 5 Oral Facial Digital Syndrome Type 5 Orofaciodigital Syndrome Type 5 Oral-Facial-Digital Syndrome Type 5 Papillon-Leage And Psaume Syndrome Orofaciodigital Syndrome, Type V

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03337	CTSK Human Pre-designed siRNA Set A		/	Unkown
HY-RS03343	CTSO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19888	Ctso Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26388	Ctso Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CTSO	MGD	MGI:2139628
Macaca mulatta	CTSO	VGNC	VGNC:71561
Rattus norvegicus	CTSO	RGD	RGD:1589156
Bos taurus	CTSO	VGNC	VGNC:53898
Felis catus	CTSO	VGNC	VGNC:61270
Others	CTSO	NCBI