COTL1 - coactosin like F-actin binding protein 1 Gene

Also Known as CLP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23406

About COTL1

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,565,596-84,618,078 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 4 paralogues. Broad expression in lymph node (RPKM 178.3), appendix (RPKM 165.6) and 20 other tissues.

Summary

This gene encodes one of the numerous actin-binding proteins which regulate the actin Cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]

COTL1 Products (1)

mRNA Protein Name
NM_021149.5 NP_066972.1 coactosin-like protein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
11583571 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
11297527 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11297527 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COTL1 Protein Structure

Cofilin_ADF

Cofilin_ADF: Cofilin/tropomyosin-type actin-binding protein (9 - 129)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

coactosin-like protein

  • coactosin-like 1

COTL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
COTL1 Q14019 PDE6H Homo sapiens Q13956
Y2H Array
25416956
Intra
COTL1 Q14019 PDE6H Homo sapiens Q13956
Y2H Prey Pooling
25416956
Intra
COTL1 Q14019 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
COTL1 Q14019 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Intra
COTL1 Q14019 ALOX5 Homo sapiens P09917
Pull Down
16924104
Cross: Cross-species interaction Intra: Intraspecies interaction

COTL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84561 COTL1 Antibody (YA4258) IHC-P, ELISA Human
HY-P84561A COTL1 Antibody (YA4258)(PBS only) IHC-P, ELISA Human

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Clivus Chordoma

  • Chordoma Of Clivus
Churg-Strauss Syndrome

  • Eosinophilic Granulomatosis With Polyangiitis

  • Allergic Granulomatous Angiitis

  • Churg-Strauss Vasculitis

  • Allergic Angiitis

  • Egpa

  • Granulomatous Allergic Angiitis

  • Allergic Granulomatosis Angiitis

  • Allergic Angiitis And Granulomatosis

  • Allergic Granulomatosis

  • Allergic Granulomatous And Angiitis

  • Css
Smith-Magenis Syndrome

  • SMS

  • Chromosome 17p11.2 Deletion Syndrome

  • 17p11.2 Microdeletion Syndrome

  • 17p11.2 Monosomy

  • Chromosome 17p Deletion Syndrome

  • Del(17)

  • P11.2

  • 17p- Syndrome

  • Deletion 17p Syndrome

  • Partial Monosomy 17p
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03055 COTL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus COTL1 MGD MGI:1919292
Rattus norvegicus COTL1 RGD RGD:1305498
Macaca mulatta COTL1 VGNC VGNC:71434
Canis familiaris COTL1 VGNC VGNC:39532
Bos taurus COTL1 VGNC VGNC:27626
Others COTL1 NCBI