Map4k4 - mitogen-activated protein kinase kinase kinase kinase 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 301363

About Map4k4

Primary_assembly 9: 42,200,278-42,326,698 forward strand.mRatBN7.2:CM026982.1

This gene has 8 transcripts (splice variants), 281 orthologues, 36 paralogues and is associated with 7 phenotypes.

Summary

Predicted to enable ATP binding activity; kinase activity; and microtubule binding activity. Involved in negative regulation of Insulin secretion involved in cellular response to glucose stimulus and negative regulation of neuron projection regeneration. Predicted to be located in focal adhesion. Predicted to be active in cytoplasm. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Map4k4 Products (2)

mRNA Protein Name
NM_001401996.1 NP_001388925.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 2
NM_001106904.2 NP_001100374.2 mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
19690174 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
18007665 RGD
involved in negative regulation of neuron projection regeneration IMP
IMP: Inferred from mutant phenotype
18007665 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-160623 Rentosertib 99.96% Phase 2

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100343 GNE-495 Inhibitor 99.49% Unkown
HY-19562 PF-06260933 Inhibitor 99.39% Unkown
HY-111754 DMX-5804 Inhibitor 99.64% Unkown
HY-168972 Famlasertib Inhibitor 99.94% Unkown
HY-125012 MAP4K4-IN-3 Inhibitor 99.77% Unkown
HY-156715 MASTL-IN-1 Inhibitor 99.54% Unkown
HY-132290 TGFβRI-IN-3 Inhibitor 98.21% Unkown
HY-W003471 Pyrrolo[2,1-f][1,2,4]triazin-4-amine Inhibitor / Unkown
HY-U00428A GNE 220 hydrochloride Inhibitor 98.22% Unkown
HY-137340 WH-10417-099 Degrader 98.14% Unkown
HY-156523 TNIK&MAP4K4-IN-1 99.73% Unkown
HY-19562A PF-06260933 hydrochloride Inhibitor 99.42% Unkown
HY-U00428 GNE 220 Inhibitor / Unkown
HY-123965 PF-06745013 Inhibitor / Unkown
HY-162922 MAP4K4-IN-6 Inhibitor / Unkown
HY-RS08080 MAP4K4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08081 Map4k4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08082 Map4k4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W207224 F1386-0303 Inhibitor / Unkown
HY-W402208 MAP4K4-IN-7 Inhibitor / Unkown
HY-178775 PI4K-IN-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map4k4 NCBI NCBI:9448