IARS1 - isoleucyl-tRNA synthetase 1 Gene

Also Known as IRS; IARS; ILRS; ILERS; GRIDHH; PRO0785

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 3376

Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking Amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I Aminoacyl-tRNA Synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]

IARS1 Products (1)

mRNA Protein Name
NM_001378582.1 NP_001365511.1 isoleucine--tRNA ligase, cytoplasmic isoform 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
24337748 GOA
enables isoleucine-tRNA ligase activity IDA
IDA: Inferred from direct assay
8052601 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9556618 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within isoleucyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
8052601 GOA
involved in isoleucyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
8052601 GOA
Cellular Component GO Annotation Evidence References Source
part of aminoacyl-tRNA synthetase multienzyme complex IDA
IDA: Inferred from direct assay
19131329 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
8052601 GOA
located in cytosol IDA
IDA: Inferred from direct assay
19289464 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

isoleucine--tRNA ligase, cytoplasmic

  • isoleucine tRNA ligase 1, cytoplasmic

IARS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IARS1 P41252 EPRS1 Homo sapiens P07814
Anti Tag CoIP
33961781
Intra
IARS1 P41252 EPRS1 Homo sapiens P07814
Pull Down
9556618
Intra
IARS1 P41252 EPRS1 Homo sapiens P07814
Crosslink
30021884
Intra
IARS1 P41252 EPRS1 Homo sapiens P07814
SPR
9556618
Intra
IARS1 P41252 EPRS1 Homo sapiens P07814
Y2H
10913161
Intra
IARS1 P41252 EPRS1 Homo sapiens P07814
Y2H
9556618
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (31)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00028 AARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01933 CARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03532 DARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07532 LARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15739 WARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17458 Aars1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162407 I-As-1 Inhibitor / Unkown
HY-P5433F IRS-1 Peptide, FAM labeled Substrate / Unkown
HY-RS05279 GARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06507 IARS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06917 IRS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07071 KARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08153 MARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09036 NARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11676 RARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12448 SARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15604 VARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16895 Irs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19198 Gars1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19754 Wars1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20900 Dars1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21627 Lars1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22566 Iars2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22670 Nars1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23337 Irs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23915 Aars1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25686 Gars1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26251 Wars1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27417 Dars1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28145 Lars1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29085 Iars2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown