CUTA - cutA divalent cation tolerance homolog Gene

Also Known as ACHAP; C6orf82

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51596

About CUTA

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,416,442-33,418,107 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 112 orthologues. Ubiquitous expression in thyroid (RPKM 52.9), adrenal (RPKM 52.0) and 25 other tissues.

Summary

Enables enzyme binding activity. Involved in protein localization. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

CUTA Products (5)

mRNA	Protein	Name
NM_001014433.3	NP_001014433.2	protein CutA isoform 1 precursor
NM_001014837.2	NP_001014837.1	protein CutA isoform 1 precursor
NM_001014838.2	NP_001014838.1	protein CutA isoform 1 precursor
NM_001014840.2	NP_001014840.1	protein CutA isoform 3 precursor
NM_015921.3	NP_057005.1	protein CutA isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	10800960	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein localization	IDA IDA: Inferred from direct assay	10800960	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	10800960	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUTA Protein Structure

CutA1

0
100
179 a.a.

Protein Preferred Names	Protein Names
protein CutA	acetylcholinesterase-associated protein

CUTA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CUTA	O60888	FBLIM1	Homo sapiens	Q8WUP2	Y2H Array	31515488
Intra	CUTA	O60888	FBLIM1	Homo sapiens	Q8WUP2	Validated Y2H	25416956
Intra	CUTA	O60888	FBLIM1	Homo sapiens	Q8WUP2	Anti Tag CoIP	33961781
Intra	CUTA	O60888	NR4A1	Homo sapiens	P22736	TAP	20195357
Intra	CUTA	O60888	NR4A1	Homo sapiens	P22736	Display Tech	20195357

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CUTA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7847	CutA Protein, Human (His)	O60888-3 (M1-P156)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Optic Atrophy 3, Autosomal Dominant	Optic Atrophy 3 OPA3 Autosomal Dominant Optic Atrophy And Cataract Optic Atrophy And Cataract, Autosomal Dominant Autosomal Dominant Optic Atrophy Type 3 Optic Atrophy 3 With Cataract Opa3, Autosomal Dominant Adoac Optic Atrophy, Cataract, And Neurologic Disorder Autosomal Dominant Optic Atrophy 3 Optic Atrophy Type 3 Optic Atrophy 3 Autosomal Dominant Atrophy, Optic, Type 3, Autosomal Dominant 3-Methylglutaconic Aciduria Type 3
Intestinal Tuberculosis	Tuberculosis Of Intestine Tuberculosis Of Intestines
Cystoisosporiasis	Isosporiasis Infection By Isospora Belli And Isospora Hominis Isosporosis Infection By Isospora Belli Or Isospora Hominis Isospora Belli Or Hominis Infection Coccidial Infestation Coccidiosis Coccidial Dysentery Intestinal Coccidiosis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03367	CUTA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18347	Cuta Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24826	Cuta Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CUTA	VGNC	VGNC:39736
Felis catus	CUTA	VGNC	VGNC:61289
Macaca mulatta	CUTA	VGNC	VGNC:71447
Rattus norvegicus	CUTA	RGD	RGD:1303306
Bos taurus	CUTA	VGNC	VGNC:27837
Mus musculus	CUTA	MGD	MGI:1914925
Others	CUTA	NCBI