MIS12 - MIS12 kinetochore complex component Gene

Also Known as MTW1; hMis12; KNTC2AP; 2510025F08Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79003

About MIS12

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,486,374-5,490,811 (from NCBI)

This gene has 6 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in thyroid (RPKM 7.6), lymph node (RPKM 6.6) and 25 other tissues.

Summary

Involved in attachment of mitotic spindle microtubules to kinetochore and kinetochore assembly. Located in kinetochore and nucleus. Part of MIS12/MIND type complex. [provided by Alliance of Genome Resources, Apr 2022]

MIS12 Products (5)

mRNA Protein Name
NM_001258217.2 NP_001245146.1 protein MIS12 homolog
NM_001258218.2 NP_001245147.1 protein MIS12 homolog
NM_001258219.1 NP_001245148.1 protein MIS12 homolog
NM_001258220.1 NP_001245149.1 protein MIS12 homolog
NM_024039.3 NP_076944.1 protein MIS12 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15371340 GOA
Biological Process GO Annotation Evidence References Source
involved in attachment of mitotic spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
23891108 GOA
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
12515822 GOA
involved in kinetochore assembly IDA
IDA: Inferred from direct assay
16585270 GOA
Cellular Component GO Annotation Evidence References Source
part of MIS12/MIND type complex IDA
IDA: Inferred from direct assay
16585270 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
15371340 GOA
part of outer kinetochore IDA
IDA: Inferred from direct assay
24530301 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIS12 Protein Structure

Mis12

Mis12: Mis12 protein (8 - 154)

  • 0
  • 100
  • 205 a.a.
Protein Preferred Names Protein Names

protein MIS12 homolog

  • MIS12 homolog

MIS12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MIS12 Q9H081 DSN1 Homo sapiens Q9H410
Anti Tag CoIP
35271311
Intra
MIS12 Q9H081 DSN1 Homo sapiens Q9H410
TAP
15371340
Intra
MIS12 Q9H081 DSN1 Homo sapiens Q9H410
BRET
37398436
Intra
MIS12 Q9H081 DSN1 Homo sapiens Q9H410
Anti Tag CoIP
26496610
Intra
MIS12 Q9H081 DSN1 Homo sapiens Q9H410
BiLC
37398436
Intra
MIS12 Q9H081 DSN1 Homo sapiens Q9H410
TAP
20360068
Intra
MIS12 Q9H081 PMF1 Homo sapiens Q6P1K2
Anti Tag CoIP
35271311
Intra
MIS12 Q9H081 PMF1 Homo sapiens Q6P1K2
TAP
15371340
Intra
MIS12 Q9H081 PMF1 Homo sapiens Q6P1K2
Lumier
37398436
Intra
MIS12 Q9H081 PMF1 Homo sapiens Q6P1K2
TAP
24981860
Intra
MIS12 Q9H081 PMF1 Homo sapiens Q6P1K2
Y2H Prey Pooling
25416956
Intra
MIS12 Q9H081 PMF1 Homo sapiens Q6P1K2
BRET
37398436
Intra
MIS12 Q9H081 PMF1 Homo sapiens Q6P1K2
BiLC
37398436
Intra
MIS12 Q9H081 PMF1 Homo sapiens Q6P1K2
Y2H Prey Pooling
32296183
Intra
MIS12 Q9H081 PMF1 Homo sapiens Q6P1K2
Anti Tag CoIP
26496610
Intra
MIS12 Q9H081 PMF1 Homo sapiens Q6P1K2
Y2H Array
32296183
Intra
MIS12 Q9H081 PMF1 Homo sapiens Q6P1K2
TAP
20360068
Intra
MIS12 Q9H081 PMF1 Homo sapiens Q6P1K2
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08463 MIS12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MIS12 RGD RGD:1564837
Felis catus MIS12 VGNC VGNC:63516
Mus musculus MIS12 MGD MGI:1914389
Macaca mulatta MIS12 VGNC VGNC:99170
Bos taurus MIS12 VGNC VGNC:31484
Others MIS12 NCBI