VMP1 - vacuole membrane protein 1 Gene

Also Known as EPG3; TANGO5; TMEM49

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81671

About VMP1

Cytogenetic location: 17q23.1 Genomic coordinates (GRCh38): 17:59,707,654-59,842,255 (from NCBI)

This gene has 17 transcripts (splice variants), 264 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 60.7), appendix (RPKM 49.2) and 25 other tissues.

Summary

This gene encodes a transmembrane protein that plays a key regulatory role in the process of Autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers Autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]

VMP1 Products (10)

mRNA	Protein	Name
NM_001329394.2	NP_001316323.1	vacuole membrane protein 1 isoform 1
NM_001329395.2	NP_001316324.1	vacuole membrane protein 1 isoform 2
NM_001329396.2	NP_001316325.1	vacuole membrane protein 1 isoform 3
NM_001329397.2	NP_001316326.1	vacuole membrane protein 1 isoform 4
NM_001329398.2	NP_001316327.1	vacuole membrane protein 1 isoform 5
NM_001329399.2	NP_001316328.1	vacuole membrane protein 1 isoform 6
NM_001329400.2	NP_001316329.1	vacuole membrane protein 1 isoform 7
NM_001329401.2	NP_001316330.1	vacuole membrane protein 1 isoform 8
NM_001329402.2	NP_001316331.1	vacuole membrane protein 1 isoform 9
NM_030938.5	NP_112200.2	vacuole membrane protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phospholipid scramblase activity	IDA IDA: Inferred from direct assay	33850023	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17724469	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	28890335	GOA
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	30093494	GOA
involved in autophagosome membrane docking	IDA IDA: Inferred from direct assay	28890335	GOA
involved in autophagy	IDA IDA: Inferred from direct assay	28890335	GOA
involved in cell junction assembly	IMP IMP: Inferred from mutant phenotype	17724469	GOA
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	17724469	GOA
involved in lipoprotein transport	IMP IMP: Inferred from mutant phenotype	31526472	GOA
involved in mitochondrion-endoplasmic reticulum membrane tethering	IDA IDA: Inferred from direct assay	28890335	GOA
involved in organelle localization by membrane tethering	IDA IDA: Inferred from direct assay	28890335	GOA
involved in positive regulation of ATPase-coupled calcium transmembrane transporter activity	IDA IDA: Inferred from direct assay	28890335	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17724469	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	28890335	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
vacuole membrane protein 1	ectopic P-granules autophagy protein 3 homolog

VMP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VMP1	Q96GC9	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	VMP1	Q96GC9	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	VMP1	Q96GC9	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	VMP1	Q96GC9	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	VMP1	Q96GC9	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	VMP1	Q96GC9	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	VMP1	Q96GC9	SLC39A9	Homo sapiens	Q9NUM3	Validated Y2H	32296183
Intra	VMP1	Q96GC9	SLC39A9	Homo sapiens	Q9NUM3	Y2H Prey Pooling	32296183
Intra	VMP1	Q96GC9	SLC39A9	Homo sapiens	Q9NUM3	Y2H Array	32296183
Intra	VMP1	Q96GC9	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	VMP1	Q96GC9	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	VMP1	Q96GC9	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	VMP1	Q96GC9	BECN1	Homo sapiens	Q14457	Anti Bait CoIP	23316280
Intra	VMP1	Q96GC9	BECN1	Homo sapiens	Q14457	Anti Tag CoIP	23316280

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pancreatitis	Mumps Pancreatitis
Acute Pancreatitis	Pancreatitis Pancreatitis, Acute Necrotizing Pancreatitis Nos Acute Pancreas Inflammation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15665	VMP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22356	Vmp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	VMP1	RGD	RGD:70367
Canis familiaris	VMP1	VGNC	VGNC:49873
Macaca mulatta	VMP1	VGNC	VGNC:104673
Mus musculus	VMP1	MGD	MGI:1923159
Bos taurus	VMP1	VGNC	VGNC:36806
Felis catus	VMP1	VGNC	VGNC:66951
Others	VMP1	NCBI