MED24 - mediator complex subunit 24 Gene

Also Known as MED5; CRSP4; ARC100; THRAP4; CRSP100; DRIP100; TRAP100

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9862

About MED24

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:40,019,104-40,054,408 (from NCBI)

This gene has 33 transcripts (splice variants) and 220 orthologues. Ubiquitous expression in testis (RPKM 18.9), brain (RPKM 13.4) and 25 other tissues.

Summary

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MED24 Products (4)

mRNA Protein Name
NM_001079518.2 NP_001072986.1 mediator of RNA polymerase II transcription subunit 24 isoform 2
NM_001267797.2 NP_001254726.1 mediator of RNA polymerase II transcription subunit 24 isoform 2
NM_001330211.2 NP_001317140.1 mediator of RNA polymerase II transcription subunit 24 isoform 3
NM_014815.4 NP_055630.2 mediator of RNA polymerase II transcription subunit 24 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear thyroid hormone receptor binding IDA
IDA: Inferred from direct assay
10198638 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24882805 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
12218053 GOA
enables transcription coregulator activity IDA
IDA: Inferred from direct assay
10198638 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10198638 GOA
involved in positive regulation of transcription initiation by RNA polymerase II IDA
IDA: Inferred from direct assay
12218053 GOA
Cellular Component GO Annotation Evidence References Source
part of core mediator complex IPI
IPI: Inferred from physical interaction
24882805 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10235267 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED24 Protein Structure

Med24_N

Med24_N: Mediator complex subunit 24 N-terminal (1 - 987)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 989 a.a.
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 24

  • CRSP complex subunit 4

MED24 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MED24 O75448 MED14 Homo sapiens O60244
Anti Tag CoIP
33961781
Intra
MED24 O75448 MED16 Homo sapiens Q9Y2X0
Anti Tag CoIP
33961781
Intra
MED24 O75448 MED25 Homo sapiens Q71SY5
Anti Tag CoIP
33961781
Intra
MED24 O75448 MED25 Homo sapiens Q71SY5
Anti Tag CoIP
24882805
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16294 Med24 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08293 MED22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08295 MED24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MED24 RGD RGD:1564565
Bos taurus MED24 VGNC VGNC:31361
Felis catus MED24 VGNC VGNC:63438
Mus musculus MED24 MGD MGI:1344385
Canis familiaris MED24 VGNC VGNC:43132
Others MED24 NCBI