country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-W739986

Copy Link Print Information

2-Hydroxy nevirapine

Name: 2-Hydroxy nevirapine
Brand: MedChemExpress
SKU: HY-W739986
Availability: PreOrder

(Synonyms: 2-OH NVP)

2-Hydroxy nevirapine (2-OH NVP) is a phase I metabolite of Nevirapine (HY-10570) and an Aryl Hydrocarbon Receptor activator. It induces hepatic Apolipoprotein A1 levels and modulates paraoxonase-1 enzyme activity. 2-Hydroxy nevirapine is used in research on atherosclerosis and HIV-1 infection.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 254889-31-1
Formule: C₁₅H₁₄N₄O₂
Masse moléculaire:282.30

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

2-Hydroxy nevirapine Chemical Structure

CAS No.: 254889-31-1

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

2-OH-NVP (300 μM; 12 days) increases ApoA1 levels by 86% after 12 days of incubation in 3D primary rat hepatocyte spheroid cultures^[1].
2-Hydroxy-nevirapine (300 μM; 4 days) induces CYP1A1/1A2 activity in 3D primary cultures of rat hepatocytes^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 254889-31-1
Masse moléculaire 282.30
Formule C₁₅H₁₄N₄O₂
SMILES

O=C1C=C(C)C(N2)=C(N1)N(C3CC3)C4=NC=CC=C4C2=O
Synonyms

2-OH NVP
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Marinho AT, et al. The 2-hydroxy-nevirapine metabolite as a candidate for boosting apolipoprotein A1 and for modulating anti-HDL antibodies. Pharmacological research. 2021 Mar;165:105446. [Content Brief]

[2]. Aline T, et al. Development and validation of an HPLC-UV method for quantifying nevirapine and its main phase I metabolites in human blood. Anal. Methods 2014; 6 (5): 1575-1580.

[3]. Pinheiro PF, et al. Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats. Chemico-biological interactions. 2015 May 25;233:115-21.

[4]. Marinho AT, et al. Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2016 Jan 20;82:147-53.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis