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SZL P1-41

13 Cited Publications
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Based on 13 publication(s) in Google Scholar

SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities.

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  • Pureté: 99.07%
  • CAS No.: 222716-34-9
  • Formule: C24H24N2O3S
  • Masse moléculaire:420.52
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • SZL P1-41 Chemical Structure
    SZL P1-41 Chemical Structure
  • Experimental Validation Results for SZL P1-41
  • Experimental Validation Results for SZL P1-41
  • Experimental Validation Results for SZL P1-41
  • Experimental Validation Results for SZL P1-41
  • Experimental Validation Results for SZL P1-41
CAS No.: 222716-34-9
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  • SZL P1-41 Chemical Structure
    SZL P1-41 Chemical Structure
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    SZL P1-41 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Jul 13;13(7):606. [Abstract]

    Customer Validation
     Dual inhibition of Aur-A and SKP2 significantly increased protein levels of C-Cas-3, p21, p27, FOXO3A and decreased p-Aur-A, SKP2 and p-FOXO3A in ccRCC cells. 769-P cells were treated with MLN8237 (10 μM) or SZL P1-41 (20 μM), or combination of the two compounds, followed by the IB assay with indicated antibodies.

  • 1/16

    SZL P1-41 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Jul 13;13(7):606. [Abstract]

    Customer Validation
     Immunohistochemical staining of xenograft tumor tissues. Tumor tissues from four groups of nude mice were fixed, sectioned, and stained with indicated antibodies treated with SZL P1-41 (80 mg/kg/day of every day for 4 weeks).

  • 1/16

    SZL P1-41 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Jul 13;13(7):606. [Abstract]

    Customer Validation
     The tumors were harvested and tumor growth was monitored treated with SZL P1-41 (80 mg/kg/day of every day for 4 weeks).

  • 1/16

    SZL P1-41 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Jul 13;13(7):606. [Abstract]

    Customer Validation
     Combination of MLN8237 and SZL P1-41 inhibited clonogenic ability in ccRCC cells. 769-P cells were treated with MLN8237 (10 μM) or SZL P1-41 (20 μM) alone or combination of the two compounds, followed by the colony formation assay.

  • 1/16

    SZL P1-41 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Jul 13;13(7):606. [Abstract]

    Customer Validation
     IC50 values of SZL P1-41 (0, 0.39, 0.78, 1.56, 3.125, 6.25, 12.5, 25, 50, and 100 μM, 48 h) in five ccRCC cell lines and HK-2 cell line by the CCK-8 assay.

  • SZL P1-41