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Cat. No.: HY-136940

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Ac22(Az8)2

Ac22(Az8)2 is a selective BCRP inhibitor (EC₅₀: 1-2 nM). Ac22(Az8)2 can restore the drug sensitivity of BCRP-overexpressing cells by inhibiting BCRP-ATPase activity, blocking drug efflux, and increasing intracellular drug accumulation. Ac22(Az8)2 can be used in the research of BCRP-mediated multidrug-resistant cancers.

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CAS No.: 2377858-65-4
Formule: C₆₆H₅₆N₆O₁₄
Masse moléculaire:1157.18

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Ac22(Az8)2 Chemical Structure

CAS No.: 2377858-65-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HFF-1	IC₅₀	>100 μM Compound: Ac22(Az8)2	Cytotoxicity against human HFF1 cells assessed as reduction in cell viability Cytotoxicity against human HFF1 cells assessed as reduction in cell viability	[PMID: 31465686]
NIH3T3	IC₅₀	>100 μM Compound: Ac22(Az8)2	Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability	[PMID: 31465686]

Chemical Information

CAS No. 2377858-65-4
Masse moléculaire 1157.18
Formule C₆₆H₅₆N₆O₁₄
SMILES

O=C(C(OCC1=CC=CC(C(OC)=O)=C1)=C(C2=CC=C(OCCOCCN3N=NC(C4=CC(C5=CN(CCOCCOC6=CC=C(C7=C(OCC8=CC(C(OC)=O)=CC=C8)C(C(C=CC=C9)=C9O7)=O)C=C6)N=N5)=CC=C4)=C3)C=C2)O%10)C%11=C%10C=CC=C%11
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhu X, et al. Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors. J Med Chem. 2019 Sep 26;62(18):8578-8608. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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