AChE/BChE-IN-1
AChE/BChE-IN-1 is a potent and brain-penetrant dual inhibitor of Acetylcholinesterase and Butyrylcholinesterase, with IC50s of 1.06 and 7.3 nM for hAChE and hBChE, respectively. AChE/BChE-IN-1 also has antioxidant activity. AChE/BChE-IN-1 can be used for the research of Alzheimer’s disease.
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- CAS No.: 2720624-42-8
- Formule: C32H35ClN6O3
- Masse moléculaire:587.11
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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AChE |
BChE |
In Vitro
AChE/BChE-IN-1 (compound 5i) is notactive against hBACE-1 at the tested concentration (1 μM)[1].
AChE/BChE-IN-1 scavenges the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, with an IC50 of 92.0 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:AβPPswe/PS-1 double transgenic male mice (10 months)[1]
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Dosage:2 mg/kg
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Administration:I.p. 3 times per week for 4 weeks
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Result:Significantly enhanced learning and memory.
Reduced Aβ42/Aβ40 ratio in the hippocampus.
Increased the strength of synaptic transmission, without affecting long-term potentiation (LTP).
Decreased the levels of oxidative stress and neuroinflammation markers in the hippocampus.
Chemical Information
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CAS No. 2720624-42-8
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Masse moléculaire 587.11
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Formule C32H35ClN6O3
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SMILES
O=C(NCC1=CC=C(O)C(OC)=C1)CC2=CN(CCCCC3=CC(C4)CC5=NC6=CC(Cl)=CC=C6C(N)=C5C4C3)N=N2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/BChE-IN-1 Related Classifications
HY-131971 Related Classifications
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