AChE-IN-116
AChE-IN-116 is a selective acetylcholinesterase (AChE) inhibitor with an electric eel AChE IC50 of 1.60 μM and Ki of 1.72 μM. AChE-IN-116 exhibits weak ability to scavenge DPPH radical. AChE-IN-116 can be used for the research of Alzheimer's disease.
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- Formule: C29H34N6O3
- Masse moléculaire:514.62
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
eel AChE 1.60 μM (IC50) |
eel AChE 1.72 μM (Ki) |
equine serum BChE >100 μM (IC50) |
In Vitro
AChE-IN-116 (Compound 9 s) potently and selectively inhibits electric eel AChE with an IC50 of 1.60 μM, showing 29.85-fold greater selectivity for AChE over equine serum BuChE[1].
AChE-IN-116 (0.80-3.20 μM) acts as a mixed-type inhibitor of electric eel AChE with an inhibition constant (Ki) of 1.72 μM[1].
AChE-IN-116 binds simultaneously to the catalytic active site (CAS) and peripheral anionic site (PAS) of human AChE, but only binds to the CAS of human BuChE, consistent with its selective AChE inhibition[1].
AChE-IN-116 exhibits an IC50 of 419.24 μM against DPPH radical[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Masse moléculaire 514.62
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Formule C29H34N6O3
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SMILES
COC1=CC(CN2CCC(C2)NC3=NC=C(C=N3)C(NC4=CC=C(C=C4)C(N5CCCCC5)=O)=O)=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-116 Related Classifications
HY-183303 Related Classifications
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