AGU661
AGU661 is a Microsomal prostaglandin E2 synthase 1 (mPGES-1) inhibitor with an IC50 of 0.22 nM. AGU661 lowers PGE2 formation in human pro-inflammatory M1 macrophages and activated monocytes without affecting other lipid mediator pathways. AGU661 has unfavorable physicochemical properties with poor metabolic stability and strong plasma protein binding tendencies. AGU661 into PLGA-based NPs significantly enhances its bioactivity. AGU661 can be used for inflammatory disorders research.
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- CAS No.: 3038861-75-2
- Formule: C28H21ClF6N4O2
- Masse moléculaire:594.94
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
Chemical Information
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CAS No. 3038861-75-2
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Masse moléculaire 594.94
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Formule C28H21ClF6N4O2
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SMILES
ClC(C=CC(CNC(C1(CCC1)C(F)(F)F)=O)=C2)=C2C(NC(C=C3)=CC=C3C4=NC5=CC(C(F)(F)F)=CC=C5N4)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AGU661 Related Classifications
HY-178794 Related Classifications
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